Spectrophotometric techniques to determine tranexamic acid: Kinetic studies using ninhydrin and direct measuring using ferric chloride

Spectrophotometric Determination of Alzheimer’s Drug, Memantine Hydrochloride in Biological Samples Using Ninhydrin and Ferric Chloride

“…When reacting with these free amines, a deep blue or purple color known as Ruhemann's purple is evolved [24,25]. Ninhydrin is known to yield a complex, which are applied in the determination of many pharmaceutical compounds [26][27][28][29][30][31][32][33][34].…”

Ninhydrin in synthesis of heterocyclic compounds

“…[39][40][41][42][43][44][45] Ninhydrin is extensively used to detect compounds of pharmaceutical importance [46][47][48][49][50][51][52][53][54][55][56][57] and in kinetic studies. [58][59] Scheme 1. Reaction of ninhydrin with amino acids.…”

Kinetic and Thermodynamic Spectrophotometric Technique to Estimate Gabapentin in Pharmaceutical Formulations using Ninhydrin

“…Ninhydrin reagent is used for the determination of an aliphatic primary amine or an amino acid group (Friedman 2004;Rahman & Azmi 2001a;Campins-Falco et al 1996;Arayne et al 2008;Rahman & Azmi 2001b;Nobrega Jde et al 1994;Molnar-Perl & Pinter-Szakacs 1989). The presence of an aromatic ring exhibits the response; the exhibition increases if the amino group is nearer to the ring.…”

“…It has been extensively used in the determination of the compounds of pharmaceutical importance applied to their kinetic studies (Rahman & Azmi 2001a;Campins-Falco et al 1996;Arayne et al 2008). Present study describes a direct, sensitive and precise spectrophotometric method simpler than the existing UV and HPLC methods that is free from such experimental variables as extraction step for the determination of gabapentin in reference material and pharmaceutical formulations by means of developing charge transfer complex with NIN.…”