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Nano-hydroxyapatite was synthesized by means of the hydrothermal treatment. The effects of nano-hydroxyapatite material on the behaviour of G2 liver cancer cells were explored. About 50% of cell viability was lost in nHAp material treated cells at 200 degrees C @ 5 h, followed by -30% in nHAp treated cells at 100 degrees C @ 5 h. Compared with control, nHAp material treated cells at 200 degrees C @ 5 h showed 60% and nHAp material treated cells at 100 degrees C @ 5 h showed 15% morphological change. Moreover, 50% of cell death was observed at 24 h incubation with nHAp material treated at 200 degrees C @ 5 h cells and 56% cell death at 48 h incubation and hence alters and disturbs the growth of cancer cells. In contrast, the nHAp material treated at 100 degrees C @ 5 h protects the cells and could be used for liver cancer cell treatment.

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In the present work, nanocrystalline hydroxyapatite/alumina (HAp−Al 2 O 3) composite was prepared under specially designed stir-type hydrothermal reactor. The composite was prepared at two different temperatures under autogenous pressure and analysed for crystallinity, size, shape, composition and thermomechanical stability. The electron microscopy study shows the formation of HAp−Al 2 O 3 composite nanorods with uniform distribution. The thermogravimetry analysis reveals better thermomechanical property with minimal weight loss at increased temperature. The effect of different concentrations of HAp−Al 2 O 3 composite powders against MG63 human osteosarcoma cell lines shows excellent compatibility (80%) at high concentration of 200 μg ml −1. These studies facilitate the formation of biocompatible HAp−Al 2 O 3 composite nanorods for biomedical applications.