Synthesis and characterization of hydroxyapatite/alumina ceramic nanocomposites for biomedical applications

Abstract

In the present work, nanocrystalline hydroxyapatite/alumina (HAp−Al 2 O 3) composite was prepared under specially designed stir-type hydrothermal reactor. The composite was prepared at two different temperatures under autogenous pressure and analysed for crystallinity, size, shape, composition and thermomechanical stability. The electron microscopy study shows the formation of HAp−Al 2 O 3 composite nanorods with uniform distribution. The thermogravimetry analysis reveals better thermomechanical property with minimal weight loss at increased temperature. The effect of different concentrations of HAp−Al 2 O 3 composite powders against MG63 human osteosarcoma cell lines shows excellent compatibility (80%) at high concentration of 200 μg ml −1. These studies facilitate the formation of biocompatible HAp−Al 2 O 3 composite nanorods for biomedical applications.

Ceramic Materials for Biomedical Applications: An Overview on Properties and Fabrication Processes

“…A composite material is defined as a heterogeneous combination of two or more distinct materials presenting a finite interface between them. Ceramic nanocomposites constitute an emerging research field aiming to further improve specific properties of bioceramics and to offer new opportunities for the treatment of a wide range of biomedical issues [ 59 , 60 , 61 , 62 , 63 ]. Nanocomposites are a class of composites in which one or more dimensions of the reinforcing phase is in the nanometer range (1 nm = 10 Å), typically up to 100 nm [ 64 ].…”

Synthesis of Spinel-Hydroxyapatite Composite Utilizing Bovine Bone and Beverage Can

“…However, the utilization of chemically synthesized hydroxyapatite for hard tissue replacement is limited because it is expensive, while a large quantity of material is required [3]. Furthermore, synthesized hydroxyapatite has different physicochemical properties (such as strength and chemical composition) than the natural one, leading to lower biological activity [4,5]. Therefore, extracting hydroxyapatites from biological materials has been considered to provide a cheaper and up-scalable alternative synthesis route, and to obtain physicochemical properties as close as those of the natural hydroxyapatite.…”

“…To further improve the mechanical properties of hydroxyapatite, it can be synthesized into a composite with metal/alloys [11][12][13][14], metal oxides [5,[15][16][17], or polymer [1,18]. The composite of hydroxyapatite (SHC) with a single metal element such as in the Mg/HAp system was considered to combine both advantages of biocompatibility and biodegradability in Mg and bioactivity in HAp [11,14].…”

“…Therefore, the addition of other metals as an alloying component was considered to improve the corrosion properties, such as in Mg-Sn/HAp [11] or Mg-Ca/HAp [13]. Similarly, composite of HAp with metal oxides such as ZrO 2 , TiO 2 , Al 2 O 3 [5], or MgO [17] were considered as the reinforcement to improve the HAp's mechanical stability [5]. Furthermore, bio-inert material such as the Al 2 O 3 poses no harmful effect on the human body [5].…”

“…Similarly, composite of HAp with metal oxides such as ZrO 2 , TiO 2 , Al 2 O 3 [5], or MgO [17] were considered as the reinforcement to improve the HAp's mechanical stability [5]. Furthermore, bio-inert material such as the Al 2 O 3 poses no harmful effect on the human body [5].…”