Normal children have a less collapsible upper airway in response to subatmospheric pressure administration (P(NEG)) during sleep than normal adults do, and this upper airway response appears to be modulated by the central ventilatory drive. Children have a greater ventilatory drive than adults. We, therefore, hypothesized that children have increased neuromotor activation of their pharyngeal airway during sleep compared with adults. As infants have few obstructive apneas during sleep, we hypothesized that infants would have an upper airway that was resistant to collapse. We, therefore, compared the upper airway pressure-flow (V) relationship during sleep between normal infants, prepubertal children, and adults. We evaluated the upper airway response to 1). intermittent, acute P(NEG) (infants, children, and adults), and 2). hypercapnia (children and adults). We found that adults had a more collapsible upper airway during sleep than either infants or children. The children exhibited a vigorous response to both P(NEG) and hypercapnia during sleep (P < 0.01), whereas adults had no significant change. Infants had an airway that was resistant to collapse and showed a very rapid response to P(NEG). We conclude that the upper airway is resistant to collapse during sleep in infants and children. Normal children have preservation of upper airway responses to P(NEG) and hypercapnia during sleep, whereas responses are diminished in adults. Infants appear to have a different pattern of upper airway activation than older children. We speculate that the pharyngeal airway responses present in normal children are a compensatory response for a relatively narrow upper airway.
Cerebellar ataxias comprise a wide range of etiologies leading to central nervous system-related motor and non-motor symptoms. Recently, a large body of evidence has demonstrated a high frequency of non-motor manifestations in cerebellar ataxias, specially in autosomal dominant spinocerebellar ataxias (SCA). Among these nonmotor dysfunctions, sleep disorders have been recognized, although still under or even misdiagnosed. In this review, we highlight the main sleep disorders related to cerebellar ataxias focusing on REM sleep behavior disorder (RBD), restless legs syndrome (RLS), periodic limb movement in sleep (PLMS), excessive daytime sleepiness (EDS), insomnia and sleep apnea. Key words: sleep disorders, ataxias, diagnosis.Distúrbios do sono nas ataxias cerebelares RESUMO As ataxias cerebelares se caracterizam por uma enorme variedade de etiologias, cursando tanto com sintomas motores como também com sintomas não motores. Recentemente, várias evidências têm demonstrado uma frequência elevada de sintomas não motores nas ataxias cerebelares, especialmente nas ataxias espinocerebelares autossômicas dominantes (SCA). Dentre os sintomas não motores, estão os distúrbios do sono, que muitas vezes são sub-diagnosticados ou pouco valorizados. Nessa revisão, enfatizamos os principais distúrbios do sono relatados nas ataxias cerebelares, como transtorno comportamental do sono REM, síndrome das pernas inquietas, movimentos periódicos das pernas no sono, sonolência diurna excessiva, insônia e apnéia do sono. Palavras-chave: distúrbios do sono, ataxias, diagnóstico.
-Objective: To determine whether mouth breathing children present the same cephalometric patterns as patients with obstructive sleep apnea syndrome (OSAS). Method: Cephalometric variables were traced and measured on vertical lateral cephalometric radiographs. The cephalometric measurements of 52 mouth and 90 nose breathing children were compared with apneic patients. The children had not undergone adenoidectomy or tonsillectomy and had not had or were not receiving orthodontic or orthopedic treatment. Results: Mouth breathing children showed same cephalometric pattern observed in patients with OSAS: a tendency to have a retruded mandible (p=0.05), along with greater inclination of the mandibular and occlusal planes (p<0.01) and a tendency to have greater inclination of the upper incisors (p=0.08). The nasopharyngeal and posterior airway spaces were greatly reduced in mouth breathing children, as observed in patients with apnea (p<0.01). Conclusion: Mouth breathing children present abnormal cephalometric parameters and their craniofacial morphology resembles that of patients with OSAS.Key WOrdS: cephalometry, mouth breathing, obstructive sleep apnea.crianças respiradoras bucais apresentam padrão cefalométrico semelhante àquele observado em pacientes adultos com síndrome da apnéia obstrutiva do sono resumo -Objetivo: determinar se crianças respiradoras bucais apresentam o mesmo padrão cefalométrico que os pacientes que tem síndrome da apnéia obstrutiva do sono (SAOS). Método: Foram traçadas radiografias laterais verticais da cabeça para a mensuração das variáveis cefalométricas. As medidas cefalométricas de 52 crianças respiradoras bucais e de 90 crianças respiradoras nasais foram comparadas à de pacientes com apnéia. Foram excluídas as crianças que haviam sido submetidas à cirurgia de remoção de amídalas ou adenóides, ou que haviam recebido tratamento ortodôntico prévio ou em andamento. Resultados: As crianças respiradoras bucais apresentaram o mesmo padrão cefalométrico observado em pacientes com SAOS: tendência a ter retrusão de mandíbula (p=0,05), assim como uma maior inclinação dos planos mandibular e oclusal (p<0,01) e tendência a ter maior inclinação dos incisivos superiores (p=0,08). O espaço da nasofaringe e o espaço aéreo posterior se apresentaram muito diminuídos nas crianças respiradoras bucais, como é observado em pacientes com SAOS (p<0,01). Conclusão: Crianças respiradoras bucais apresentam padrão cefalométrico alterado e sua morfologia craniofacial é semelhante àquela observada em pacientes com SAOS.PAlAvrAS-ChAve: cefalometria, respiração bucal, apnéia obstrutiva do sono. Obstructive sleep apnea syndrome (OSAS) in adults is characterized by repeated episodes of cessation of breathing during sleep. These episodes result from obstruction of the upper airways, which collapse at different levels ranging from the nasal fossae to the lower portion of the hypopharynx 1 . The nocturnal symptoms include snoring, restless sleep, frequent arousals, apneas and excessive sweating. The daytime problems...
-Background:Restless legs syndrome (RLS) is a chronic sensory-motor disorder characterized by unpleasant limb sensations and an irresistible urge to move. The International Restless Legs Syndrome Study Group developed the Restless Legs Syndrome Rating Scale (IRLS) to assess the severity of RLS symptoms. The objective of this study was to translate and validate the IRLS into Brazilian Portuguese. Method: The IRLS was translated into Brazilian Portuguese, analyzed, back translated to English, and compared to the original version. It was applied to 10 patients for cultural verification. The language was adjusted and the final version was administered to 30 patients (13 male, mean age 58.88±14.82). Results: There was correlation among the IRLS evaluation of three experts. Many linguistic adaptations were required to achieve cultural adequacy and the Cronbach's alpha coefficient showed reliability of 80%. Conclusion: IRLS was translated, adapted, and validated to Brazilian Portuguese language, showing good reliability and validity.KEy woRdS: restless legs syndrome, scale, severity, validation. Tradução e validação para a língua portuguesa da escala de graduação da síndrome das pernas inquietas do grupo internacional do estudo da síndrome das Pernas inquietasResumo -Introdução: A síndrome das pernas inquietas (SPI) é uma doença crônica, sensório-motora, caracterizada por sensações desagradáveis nos membros e uma urgência em movimentá-los. o Grupo Internacional de Estudos da Síndrome das Pernas Inquietas desenvolveu a Escala de Graduação da Síndrome das Pernas Inquietas (EGSPI) para avaliar a gravidade dos sintomas da SPI. Objetivo: Traduzir, adaptar culturalmente e validar a EGSPI para o português do Brasil. Método: A escala foi vertida para o português, analisada, vertida novamente para o inglês e comparada com a versão original. Foi aplicada em 10 pacientes para adequação cultural. A linguagem foi ajustada e a versão final foi aplicada em 30 pacientes (13 homens, idade média de 58,88±14,82). Resultados: Houve correlação da aplicação da escala entre três avaliadores. Foram necessárias adaptações lingüísticas para adequação cultural e o alfa de Chronbach mostrou confiabilidade de 80%. Conclusão: A EGSPI foi traduzida, adequada e validada para o português do Brasil, com boa validade e confiabilidade.PALAvRAS-CHAvE: síndrome das pernas inquietas, escala, gravidade, validação.
Oral appliances and functional orthopaedic appliances for obstructive sleep apnoea in children.
OSA patients presented subclinical manifestations of abnormal swallowing, when analyzed using nasal fibroscopy, possibly associated with neuromuscular injury caused by snoring.
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