The HLA-G and HLA-E molecules, Ki67, progesterone (PR), estrogen (ER) and androgen receptors (AR), p53, COX-2, and HER2 were studied to assess whether the biological behavior of grade I meningiomas is related to their expression. Tissue samples from 96 patients with grade I intracranial meningiomas were analyzed by immunohistochemistry on tissue microarray blocks (TMA) using antibodies specific for HLA-G, HLA-E, Ki67, PR, ER, AR, p53, COX-2, and HER2. Meningiomas were classified as small (≤2 cm, 1.0%), medium (>2 and ≤4 cm, 32.3%), and large (>4 cm, 66.7%). Tumor size was not related to recurrence/regrowth (p = 0.486), but was significantly correlated with peritumoral edema (p = 0.031) and intratumoral calcifications (p = 0.018). Recurrent meningiomas were observed in 14.6% of cases. Immunostaining for each marker was: HLA-G 100%; HLA-E 95.6%; PR 62%; ER 2.1%; AR 6.5%; p53 92.6%; COX-2 100%; HER2 0%; Ki67, mean 2.61 ± 2.29%, median 2.1%. Primary and recurrent meningiomas showed no significant relation with HLA-E and hormone receptors (p > 0.05), except for Ki67, where a higher median was observed in recurrent tumors than in primary (p = 0.014). The larger the tumor, the more severe the peritumoral edema, and the greater the presence of calcifications. Ki67 appears to be a good biomarker of recurrence/regrowth in grade I meningiomas.

y unitermos key words resumo Introdução: A mamoplastia redutora estética bilateral (MEB) é uma cirurgia que tem como objetivo reduzir o volume mamário, melhorando problemas estéticos e posturais, ou obter equilíbrio estético em pacientes submetidas a mamoplastia contralateral (MRC) a câncer de mama. A incidência de lesões mamárias nestes espécimes é variável, e a presença de câncer em uma das mamas é fator de risco conhecido para desenvolvimento de câncer na mama contralateral. Objetivos: Comparar a freqüência de lesões proliferativas epiteliais e outras alterações histopatológicas em espécimes de MEB e MRC. Materiais e métodos: Foram revistas lâminas de 867 peças cirúrgicas de MEB e 72 de MRC, anotando-se as alterações histopatológicas, com ênfase nas hiperplasias epiteliais, e relacionando-as com a faixa etária das pacientes. Resultados: A idade média das pacientes submetidas a MEB foi de 34 anos, e das submetidas a MRC, de 50,3 anos. Alterações fibrocísticas foram as lesões mais comumente diagnosticadas. Cistos e ectasia ductal estavam presentes em 50,9% das MEB e em 59,7% das MRC. Hiperplasias epiteliais foram diagnosticadas em 10,1% das MEB e em 43,1% das MRC, principalmente em mulheres com idade superior a 40 anos. Entre as hiperplasias, o tipo usual foi o mais freqüente nos dois grupos (MEB = 9,8% e MRC = 33,3%). Hiperplasias atípicas estavam presentes em 9,7% dos casos de MRC e em 0,3% de MEB. Conclusão: A incidência de hiperplasias epiteliais com e sem atipias foi maior nos casos de MRC do que nos de MEB mesmo quando as pacientes foram pareadas pela faixa etária. Mamoplastia Hiperplasias epiteliaisNeoplasia mamária abstract Background: Reduction mammaplasty is a surgery whose objective is to reduce the mammary size, improving aesthetic (MEB), or to attain of aesthetic balance in patients submitted to mammaplasty contralateral to breast cancer (MRC). The incidence of breast lesions in these specimens is variable and the previous cancer in one breast is a known risk factor for cancer in the contralateral breast. Aims: To compare the frequency of epithelial proliferative breast lesions and other histological changes in specimens of MEB and MRC. Methods: Breast surgical specimens from 867 MEB and 72 MRC had been reviewed and histological changes evaluated, with emphasis in epithelial hyperplasias relating them to patient's age. Results: The average age of patients was MEB = 34 years and MRC = 50.3 years. Fibrocystic change was the most common diagnosis. Cysts/duct estasia were present in 50.9% of MEB and 59.7% of MRC. Epithelial hyperplasia was diagnosed in 10.1% of MEB and 43.1% of MRC specimens, especially in women over 40 years. Usual hyperplasia was the most frequent type in both groups (MEB = 9.8% and MRC = 33.3%). Atypical hyperplasia was present in 0.3% MEB and 9.7% MRC cases. Conclusions: The incidence of epithelial hyperplasias was higher in MRC than in MEB specimens in spite of age.

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Use of the amniotic membrane to cover the peritoneal cavity in the reconstruction of the abdominal wall with polypropylene mesh in rats Use of the amniotic membrane to cover the peritoneal cavity in Use of the amniotic membrane to cover the peritoneal cavity in Use of the amniotic membrane to cover the peritoneal cavity in Use of the amniotic membrane to cover the peritoneal cavity in Use of the amniotic membrane to cover the peritoneal cavity in the reconstruction of the abdominal wall with polypropylene the reconstruction of the abdominal wall with polypropylene the reconstruction of the abdominal wall with polypropylene the reconstruction of the abdominal wall with polypropylene the reconstruction of the abdominal wall with polypropylene mesh in rats mesh in rats mesh in rats mesh in rats mesh in rats Uso da membrana amniótica como cobertura da cavidade abdominal na Uso da membrana amniótica como cobertura da cavidade abdominal na Uso da membrana amniótica como cobertura da cavidade abdominal na Uso da membrana amniótica como cobertura da cavidade abdominal na Uso da membrana amniótica como cobertura da cavidade abdominal na reconstrução da parede com tela de polipropileno em ratos reconstrução da parede com tela de polipropileno em ratos reconstrução da parede com tela de polipropileno em ratos reconstrução da parede com tela de polipropileno em ratos reconstrução da parede com tela de polipropileno em ratos Objective Objective: to evaluate the efficacy of the amniotic membrane used with polypropylene mesh against the formation of adhesions and its influence on healing. Methods Methods Methods Methods Methods: twenty five female Wistar rats were anesthetized for creating a parietal defect in the anterior abdominal wall. Its correction was made with polypropylene mesh alone and associated with amniotic membrane. In the control group (n=11), the screen was inserted alone. In group A (n=7) we interposed the amniotic membrane between the screen and the abdominal wall. In group B, the amniotic membrane was placed on the mesh, covering it. After seven days, the animals were euthanized for macroscopic and microscopic evaluation of healing. Results Results ResultsResults Results: adhesions were observed in all animals except one in the control group. Severe inflammation was observed in all animals in groups A and B and in three of the control group, with significant difference between them (A and B with p=0.01). Pronounced angiogenic activity was noted in one animal in the control group, six in group A and four in group B, with a significant difference between the control group and group A (p=0.002) and group B (p=0.05). The scar collagen was predominantly mature, except in five animals of the control group, with significant difference between the control group and group A (p=0.05) and group B (p=0.05). Conclusion Conclusion Conclusion Conclusion Conclusion: The amniotic membrane did not alter the formation of adhesions in the first postoperative week. There were also pronounced inflammation, high angiogenic activit...

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