Several drugs were tested, some of them for the first time, against seasickness in military personnel on transport ships on the North Atlantic ocean. All of the drugs were given three fimes a day. Of the new ones tested phenglutarmide, 2.5 mg., and cinnarazine, 7.5 mg., were significantly effective on a single trip. Somewhat less effective were atropine and orphenadrine.Ineffective new drugs were procyclidine, diethazine, cycrimine, caramiphen, pheniprazine, nialamide, phenelzine, benactyzine, and promazine.Cyclizine and meclizine, in doses of 50 mg. three times a day, were again found to be effective.
Evaluation was undertaken of several measurements in discriminating between a group of clinically normal persons and a group of persons with definite atherosclerosis manifested by clinical myocardial infaretions. Various Sf lipoprotein classes, the serum cholesterol, the beta lipoprotein cholesterol, the lipid phosphorus, and the "atherogenic index" were included in the study. The results are presented and their significance is discussed.
Twenty-five patients sustained an average weight loss of 21.7 pounds on a diet in which 73 per cent of total calories consisted of animal fat. Their "new" weight was maintained on this high-fat diet and subsequently on a low-fat diet. Standard S
f
0-12 lipoproteins were highly influenced by dietary fat intake independent of weight change. In contrast the S
f
20-400 fraction was lowered by negative caloric balance and weight reduction despite the ingestion of large amounts of animal fat. These changes were statistically highly significant. Divergent responses of different classes of beta-lipoproteins may be missed if only total beta-lipoprotein measurements are made.
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