Effect of certain drugs on the incidence of seasickness

Abstract

Several drugs were tested, some of them for the first time, against seasickness in military personnel on transport ships on the North Atlantic ocean. All of the drugs were given three fimes a day. Of the new ones tested phenglutarmide, 2.5 mg., and cinnarazine, 7.5 mg., were significantly effective on a single trip. Somewhat less effective were atropine and orphenadrine.Ineffective new drugs were procyclidine, diethazine, cycrimine, caramiphen, pheniprazine, nialamide, phenelzine, benactyzine, and promazine.Cyclizine and meclizine, in doses of 50 mg. three times a day, were again found to be effective.

Cinnarizine in the prophylaxis of seasickness: Laboratory vestibular evaluation and sea study

“…The only comparison that can be made between our results and those previously reported regards the percentage of vomiting protection in the study by Trumbull et a1. 26 The calculated percentage of protection provided by 7.5 mg cinnarizine three times a day in that study was 59%, compared with 63% for a single dose of 50 mg cinnarizine reported by us. On the other hand, we failed to show any protection against vomiting at sea by a single dose of 25 mg cinnarizine.…”

Promethazine, scopolamine and cinnarizine: comparative time course of psychological performance effects

“…In sea trials it has occasionally demonstrated significant motion sickness protection (Trumbull et al 1960;Hargreaves 1980, second trip), although it has also failed to demonstrate significant effects (Trumbull et al 1960, both other trips). Laboratory studies using replicable motion conditions, have demonstrated comparatively slight protection.…”

Cinnarizine in the Treatment of Peripheral Vascular Disease: Mechanisms Related to its Clinical Action

“…It was originally used as an antihistamine (Zolov 1961). A natural development was its use in the prevention of motion sickness (Trumbull et al 1960, Cobb et al 1976). However, it first became widely used in the United Kingdom as a specific anti-vertigo agent (Philipszoon 1962, Dix & Morales-Garcia 1972.…”