Serum Parameters as Discriminators between Normal and Coronary Groups

Abstract

Evaluation was undertaken of several measurements in discriminating between a group of clinically normal persons and a group of persons with definite atherosclerosis manifested by clinical myocardial infaretions. Various Sf lipoprotein classes, the serum cholesterol, the beta lipoprotein cholesterol, the lipid phosphorus, and the "atherogenic index" were included in the study. The results are presented and their significance is discussed.

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

“…Circulating metabolites have key roles in numerous biological pathways and consequently contribute to risk for many diseases, particularly disorders of the metabolic and cardiovascular systems 1,2 . Such metabolites have long been used for clinical risk assessment, diagnosis, prognosis and evaluation of treatment efficacy.…”

Limitations of the Serum Cholesterol Level as a Diagnostic Index of Cardiovascular Status

“…On the other hand, Brunner and Lobl (26) reviewed a group of 74 coronary patients under the age of 62 years, and found that nearly half of them had a serum cholesterol level within the upper limit of 250 mg. per 100 ml., at least one being as low as 145 mg. per 100 ml. Schlessinger et al (27) noted that total serum cholesterol concentration was an unsatisfactory discriminator between normal and coronary groups. Obviously, the so‐called “normal” serum cholesterol range of 200–250 mg. per 100 ml.…”

Lipoproteins, Cholesterol and Serum Proteins as Predictors of Myocardial Infarction

“…There is wide division of opinion as to the significance of stress. There may even be several groups of individuals prone to coronary disease' [1][2][3][4][5][6][7][8][9][10][11][12][13] the inyocardial lesions. Until more is learned about the effect of hypotension, fever, tissue necrosis, etc., during the acute episode, it will be difficult to determine which of these changes might be associated with the lipid changes occurring immediately after infarction.…”

“…Such factors do not enter into the evaluation of the men. In the men the 'e was a definite tendency for the -S [1][2][3][4][5][6][7][8][9][10] concentration to be decreased, although 6 of 22 patients studied 3 months to 10 years after occurrence of infarction had normal values.…”