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The effect of particle size of lipasomes cm the deposition of drugs into the strata of skin was evaluated using hairless mice. hamster and pig skin. fn vitro diffusion studies were performed in an attempt to find an optimum formulation for topical drug delivery as welt as to try to explain the mechanism of topica! drug delivery by fipasomes. The results indicate that an optimum particle size for optima1 drug delivery exists. The study proved that the folficular route play an important roie in determining the kinetics of drug transfer from liposomes into the skin.

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When rats are treated daily with reserpine or maintained at 4 degrees C, the level of a specific RNA coding for tyrosine hydroxylase is elevated in the adrenal gland. The increase in this specific RNA temporally precedes and is quantitatively equal to the increase in adrenal tyrosine hydroxylase enzyme activity elicited by these treatments. These results suggest that prolonged stress may lead to changes in the levels of specific RNA species in the adrenal gland.