Topical transport of hydrophilic compounds using water-in-oil nanoemulsions

Wu, Huailiang; Ramachandran, Chandrasekharan; Weiner, Norman; Roessler, Blake J.

doi:10.1016/s0378-5173(01)00671-8

Cited by 162 publications

(85 citation statements)

References 22 publications

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“…Droplet size is typically in the range of 10-100 nm. [22][23][24] They are typically composed of an aqueous phase, oil phase, surfactant, and cosurfactant. Microemulsions can be prepared by spontaneous emulsification, which offers several advantages over other drug vehicles, such as liposome and polymeric nanoparticles, including lower preparation costs, high drug loading, no need for an organic solvent, and a long shelf-life for both hydrophilic and lipophilic therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

“…Microemulsions can be prepared by spontaneous emulsification, which offers several advantages over other drug vehicles, such as liposome and polymeric nanoparticles, including lower preparation costs, high drug loading, no need for an organic solvent, and a long shelf-life for both hydrophilic and lipophilic therapeutic agents. [16][17][18][19][20][21][22][23][24][25] Numerous studies have demonstrated that microemulsions can improve drug transport through the skin compared with conventional topical preparations, such as gels, creams, and ointments. [26][27][28][29] Hence, microemulsions were used as the vehicle for transdermal delivery of citalopram in the present study.…”

Section: Introductionmentioning

confidence: 99%

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Effect of microemulsions on transdermal delivery of citalopram: optimization studies using mixture design and response surface methodology

Huang¹,

Tsai²,

Lin³

et al. 2013

IJN

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Abstract:The aim of this study was to evaluate the potential of microemulsions as a drug vehicle for transdermal delivery of citalopram. A computerized statistical technique of response surface methodology with mixture design was used to investigate and optimize the influence of the formulation compositions including a mixture of Brij 30/Brij 35 surfactants (at a ratio of 4:1, 20%-30%), isopropyl alcohol (20%-30%), and distilled water (40%-50%) on the properties of the drug-loaded microemulsions, including permeation rate (flux) and lag time. When microemulsions were used as a vehicle, the drug permeation rate increased significantly and the lag time shortened significantly when compared with the aqueous control of 40% isopropyl alcohol solution containing 3% citalopram, demonstrating that microemulsions are a promising vehicle for transdermal application. With regard to the pharmacokinetic parameters of citalopram, the flux required for the transdermal delivery system was about 1280 µg per hour. The microemulsions loaded with citalopram 3% and 10% showed respective flux rates of 179.6 µg/cm 2 and 513.8 µg/cm 2 per hour, indicating that the study formulation could provide effective therapeutic concentrations over a practical application area. The animal study showed that the optimized formulation (F15) containing 3% citalopram with an application area of 3.46 cm 2 is able to reach a minimum effective therapeutic concentration with no erythematous reaction.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of microemulsions on transdermal delivery of citalopram: optimization studies using mixture design and response surface methodology

Huang¹,

Tsai²,

Lin³

et al. 2013

IJN

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“…As a result of the sampling, the receptor compartment concentration of alaptide was corrected for sample removal and replenishment using equation: C' n = C n (V t /V t -V s ) (C' n-1 /C n-1 ); where C' n = corrected drug concentration in the n th sample, C n = measured drug concentration in the n th sample, C' n-1 = corrected drug concentration in the (n-1) th sample, C n-1 = measured drug concentration in the (n-1) th sample, V t = total volume of receptor solution, V s = volume of the sample, and C' 1 = C 1 [28]. The corrected data were expressed as the cumulative drug permeation (Q t ) per unit of skin surface area using equation: Q t = C' n /A; where A = 0.6359 cm 2 in our experiment.…”

Section: In Vitro Transdermal Permeation Experimentsmentioning

confidence: 99%

Permeation of Indomethacin through Skin Using Nanonized Alaptide

2015

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“…They are independent of molecular size of the hydrophilic solute and the nature of the aqueous phase. In addition, nanoemulsions delivery system was independent of animal skin characteristics such as the stratum corneum thickness and the follicle-type (Wu et al 2001). Thus, nanoemulsions due to their extremely small size are suitable to be used as delivery system in cosmeceuticals.…”

Section: Fabrication Rheology and Antioxidant Activity Of Palm Estermentioning

confidence: 99%

Fabrication, Rheology and Antioxidant Activity of Palm Esters-based Emulsions Loaded with Tocotrienol

Mahiran

Zahariyah³

2014

AJSTD

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Palm oil esters are wax esters derived from palm oil and oleyl alcohol. Palm oil esters have many applications due to their luxurious moisturizing properties, non-greasy and blend easily with fragrances and colours when applied on skin surface. The aim of this research was to fabricate palm esters-based emulsions cream for topical delivery, characterise the rheological properties and in vitro antioxidant activity of the palm esters-based emulsions system.Emulsions containing palm oil esters loaded with tocotrienol were obtained in two stages, with propagation of rotor-stator at 6000 r.p.m. for 5 min and further emulsified using an ultrasound at various acoustic amplitudes for another 5 min. A stress/rate controlled Kinexus Rheometer with a temperature controller was used to measure the rheological properties of the emulsion. Rheology measurements were performed at 25.0°C ± 0.1°C with 4°/40 mm cone and plate geometry. The in vitro antioxidant activity was investigated using UV-Vis spectrophotometer.The yield stress of the emulsions increased with increasing acoustic amplitudes. The viscoelasticity of the emulsions were enhanced by the increase in the oil and surfactant concentrations. The emulsions with higher oil phase concentration [30% (w/w)] showed greater elasticity which implied strong dynamic rigidity of the emulsions. The cohesive energy increased significantly with surfactant concentration especially for the emulsions with 30% (w/w) oil phase concentration. The palm oil esters emulsions containing tocotrienol gave higher Trolox equivalent antioxidant capacity values which implied higher antioxidant capability.The tocotrienol in emulsion with 30% (w/w) dispersed phase showed that they were the most stable with longest shelf life and exhibited greater inhibitory effects on the ABTS•+ .

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Topical transport of hydrophilic compounds using water-in-oil nanoemulsions

Cited by 162 publications

References 22 publications

Effect of microemulsions on transdermal delivery of citalopram: optimization studies using mixture design and response surface methodology

Effect of microemulsions on transdermal delivery of citalopram: optimization studies using mixture design and response surface methodology

Permeation of Indomethacin through Skin Using Nanonized Alaptide

Fabrication, Rheology and Antioxidant Activity of Palm Esters-based Emulsions Loaded with Tocotrienol

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