Liposomes as Carriers for Topical and Transdermal Delivery

Touítou, Elka; Junginger, Hans E.; Weiner, Norman; Nagai, Tsuneji; Mezei, Michael

doi:10.1002/jps.2600830902

Cited by 170 publications

(73 citation statements)

References 33 publications

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“…Liposomal drug formulations have been reported to have good accumulation of drug at the administration site (thus improving therapeutic efficacy) and to have fewer side effects than plain formulations [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Clinical assessment of the combination therapy with liposomal gels of tretinoin and benzoyl peroxide in acne

2001

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Section: Introductionmentioning

confidence: 99%

Clinical assessment of the combination therapy with liposomal gels of tretinoin and benzoyl peroxide in acne

2001

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“…drug delivery [6,7] 3.1 Skin penetration can be enhanced by following methods:-1. Drug/prodrug: The prodrug approach has been used to enhance the dermal and transdermal delivery of drugs with unfavorable partition coefficients the prodrug design involves addition of a promoiety to increase partition coefficient and also solubility and transport of the parent drug in the stratum conium.…”

Section: Methods For Enhancing Transdermalmentioning

confidence: 99%

Transdermal Drug Delivery System: formulation, development and evaluation-An overview

Bathe¹,

Kapoor²

2015

Int J of Biomed & Adv Res

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In a transdermal drug delivery system the drug is applied in a relatively high dosage to the inside of a patch, which is worn on the skin for an extended period of time. Through a diffusion process, the drug enters the bloodstream directly through the skin. Since there is high concentration on the patch and low concentration in the blood, the drug will keep diffusing into the blood for a long period of time, maintaining the constant concentration of drug in the blood flow. Transdermal drug delivery system was introduced to overcome the difficulties of drug delivery through oral route. The conventional oral dosage forms have significant setbacks of poor bioavailability due to hepatic first pass metabolism. To improve characters of transdermal drug delivery system (TDDS) was emerged, which will improve the therapeutic efficacy and safety of drugs by specific sites within the body, thereby reducing both the size and number of doses. This review article describes the methods of preparation of different types of transdermal patches such as matrix patches, reservoir type, membrane matrix, drug-in-adhesive patches and micro reservoir patches.

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“…To enhance the penetration activity of the drug entity various enhancers are used. Both physical and chemical methods are being used to develop enhancement technique 11 . Iontophoresis is one of the physical methods.…”

Section: Ijpsr (2017) Volume 8 Issue 10 (Review Article)mentioning

confidence: 99%

Untitled

2017

IJPSR

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ABSTRACT:The skin has been used as a medium for systemic delivery of therapeutic agents. The resistance provided by the stratum corneum is the major barrier in delivering of the agents through skin. Due to this the number of drug molecules used under this category is limited. Iontophoresis is an efficient technique for physically enhancing conveyance of molecules across skin for local and systemic effects. The main feature offered by iontophoresis is the control offered by it in dose modulation by adjustment of current applied to undergo the process. It is suitable as an alternative for parenteral route as it is pain free and cost effective technique. The flux associated with iontophoretic treatment is described along with its applications in the article. The future aspects of iontophoretic treatment and the medications currently available are included in this article. Iontophoresis as a treatment regimen has gained popularity in relatively less treatment methodology but the concept should be well popularized as it offers enhancement to transdermal drug delivery system. This system being non invasive, pain free and with minimum side effects must be made use of in most of the treatment regimen.

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Liposomes as Carriers for Topical and Transdermal Delivery

Cited by 170 publications

References 33 publications

Clinical assessment of the combination therapy with liposomal gels of tretinoin and benzoyl peroxide in acne

Clinical assessment of the combination therapy with liposomal gels of tretinoin and benzoyl peroxide in acne

Transdermal Drug Delivery System: formulation, development and evaluation-An overview

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