Introduction
and Importance: Coronavirus Disease 2019 (COVID-19) has become a pandemic since the beginning of 2020. COVID-19 is also spreading very rapidly in Indonesia and so far, no definitive therapy has been found.
Case presentation
We report two cases of confirmed COVID-19 with moderate pneumonia, who received 400 ml of convalescent plasma and showed improvements in clinical, laboratory and radiological examinations.
Clinical discussion
Passive immunotherapy is generally more effective when given early. Plasma transfusion is more beneficial when given before clinical conditions become severe. Some studies have shown that therapy with convalescent plasma can contribute to a longer survival and a lower length of stay.
Conclusion
Convalescent plasma can be used as an adjunctive therapy option for patients with moderate COVID-19.
Clinical manifestations and results of investigations using imaging methods for pulmonary and extrapulmonary tuberculosis (TB) are often mistaken for malignancy, so TB is referred to as a "great imitator." This study aims to describe pulmonary TB and extrapulmonary TB patients at the Siloam MRCCC Semanggi Cancer Specialist Hospital in 2018-2020. A retrospective study design was used in the study with a sample of 71 patients according to the inclusion criteria. The research instrument used was the archives of the Anatomical Pathology Laboratory of the Siloam MRCCC Semanggi Cancer Special Hospital in 2018-2020. Pulmonary TB and extrapulmonary TB results were obtained in 2018 14 patients (19.7%), 31 patients (43.6%) in 2019, and 26 patients (36.7%) in 2020. Most TB occurred in the age range of 21-30 years (36.6%) and female sex (67.6%). Based on the location of the lesion, extrapulmonary TB was found in 64 patients (90.1%) and pulmonary TB in 7 patients (9.9%). Clinical diagnosis showed that 12 patients (17%) were suspected of malignancy, and 55 patients (77.4%) were not. After histopathological examination, 43 tuberculous lymphadenites (60.6%), seven bone and joint TB (9.9%), six lung TB (8.5%), four soft tissue TB (5.6%), 4 Genitourinary TB (5.6%), four gastrointestinal & peritoneal TB (5.6%), two cutaneous TB (2.8%), and one central nervous system TB (1.4%). Risk factors play an important role in the occurrence of pulmonary TB and extrapulmonary TB. Histopathological examination is important to exclude the possibility of malignancy in patients with pulmonary TB and extrapulmonary TB so that treatment can be carried out quickly and accurately.
In December 2019, a mysterious pneumonia case was first reported in Wuhan, Hubei Province known as COVID-19, and its etiologic agent, SARS-Cov-2 virus. C-Reactive Protein (CRP) is a homopentameric protein that appears in inflammatory conditions. Erythrocyte sedimentation rate (ESR) increases in both acute and chronic inflammations. This study aimed to determine the correlation between CRP and ESR concentrations with the status of PCR diagnostic test results in patients. It was a correlation study with a cross-sectional approach. The data was taken from results from the first PCR and laboratory examination of the patients for COVID-19. The population of this study was patients under monitoring (PDP) for COVID-19 who were treated at a hospital in East Bekasi, West Java. The sample for this study was 65 people, consisting of 28 (43.1%) negative COVID-19 patients and 37 (56.9%) positive COVID-19 patients. The results showed that at the start of the PCR test for COVID-19, there was a weakly significant increase in CRP (r=0.311), and there was a significant relationship between the COVID-19 PCR results and the patient's CRP levels (p=0.040) in the age group 1-40 years. In addition, there was an increase in the respiratory rate in patients with high CRP with a weak significance (r=0.366), and a significant relationship between the CRP test results and the patients’ respiratory rate (p=0.026). In addition, there was a strong relationship between CRP increase and LED increase (p=0.000).
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