Circular dichroism (CD) is an interesting phenomenon originating from the interaction of light with chiral molecules or other nanostructures lacking mirror symmetries in three-dimensional (3D) or two-dimensional (2D) space. While the observable effects of optical chirality are very weak in most of the natural materials, they can be designed and significantly enhanced in synthetic chiral structures, where the spatial symmetry of their component are broken on a nanoscale. Therefore, fabrication of composites capable of cheap, time-saving, and giant CD is desirable for the advanced optical technologies. Here, the giant CD of large-area metal nanocrescent array structures was investigated theoretically and experimentally. The largest value of the CD spectrum measured was larger than 0.5, and the CD spectrum was tuned effectively and extensively while maintaining a large peak intensity, which can be attributed to the selective excitation of the lattice surface modes (LSMs) by circularly polarized light. The analysis of the extrinsic chiral structure shows potential applications in chiral molecule sensing and polarizing imaging.
Cardioneuroablation (CNA) is proposed as a promising therapy for patients with sinoatrial node dysfunction (SND) that is mediated by excessive vagal tone. However, a series of urgent questions about CNA remain unanswered. From December 2020 to March 2022, six patients with symptomatic SND who underwent CNA were summarized in this report. Sequential CNA targeting Ao-SVC GP, PMLGP, RAGP, and LSGP was performed in patients, guided by fractionated intracardiac electrograms and dynamically evaluated by extracardiac vagal stimulation (ECVS). The results showed that Ao-SVC GP ablation led to a significant increase in heart rate (HR) and the elimination of sinus arrest evoked by ECVS, while the vagal responses of atrial ventricular block were eliminated by the ablation of PMLGP and LSGP. Post-procedure HR increased up to 64–86% of the maximum HR of an atropine test at baseline. The median HR from Holter monitoring increased from 52.8 ± 2.1 bpm at baseline to 73.0 ± 10.4 bpm after the procedure (p = 0.012) and to 71.3 ± 10.1 bpm at the six-month follow-up (p = 0.011). Bradycardia-related symptoms disappeared in all patients at the six-month follow-up. This case series reveals the feasibility of using the ECVS-assisted sequential CNA technique and indicates the critical role of ECVS in dynamically evaluating the impact of sequential CNA on the vagal control of SAN and AVN.
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