Localized intra‐articular delivery of anti‐inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of raid clearance within few hours of injection. A new class of polymer is developed that forms self‐assembled nanoparticles ranging from 300 to 900 nm and demonstrates particle size dependent prolonged retention in intra‐articular joint spaces compared to bolus protein over a period of 14 d.

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Self-driving cars must detect other vehicles and pedestrians in 3D to plan safe routes and avoid collisions. State-of-the-art 3D object detectors, based on deep learning, have shown promising accuracy but are prone to over-fit to domain idiosyncrasies, making them fail in new environmentsa serious problem if autonomous vehicles are meant to operate freely. In this paper, we propose a novel learning approach that drastically reduces this gap by fine-tuning the detector on pseudo-labels in the target domain, which our method generates while the vehicle is parked, based on replays of previously recorded driving sequences. In these replays, objects are tracked over time, and detections are interpolated and extrapolated-crucially, leveraging future information to catch hard cases. We show, on five autonomous driving datasets, that fine-tuning the object detector on these pseudo-labels substantially reduces the domain gap to new driving environments, yielding drastic improvements in accuracy and detection reliability.

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Advances in perception for self-driving cars have accelerated in recent years due to the availability of large-scale datasets, typically collected at specific locations and under nice weather conditions. Yet, to achieve the high safety requirement, these perceptual systems must operate robustly under a wide variety of weather conditions including snow and rain. In this paper, we present a new dataset to enable robust autonomous driving via a novel data collection process -data is repeatedly recorded along a 15 km route under diverse scene (urban, highway, rural, campus), weather (snow, rain, sun), time (day/night), and traffic conditions (pedestrians, cyclists and cars). The dataset includes images and point clouds from cameras and LiDAR sensors, along with high-precision GPS/INS to establish correspondence across routes. The dataset includes road and object annotations using amodal masks to capture partial occlusions and 3D bounding boxes. We demonstrate the uniqueness of this dataset by analyzing the performance of baselines in amodal segmentation of road and objects, depth estimation, and 3D object detection. The repeated routes opens new research directions in object discovery, continual learning, and anomaly detection. Link to Ithaca365: https://ithaca365.mae.cornell.edu/

Localized intra‐articular delivery of anti‐inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of rapid clearance within few hours of injection. On page 1562, A. J. García and co‐workers report a new class of polymer that forms self‐assembled nanoparticles with therapeutic proteins for prolonged retention in intra‐articular joint spaces compared to bolus protein doses.