Drug Delivery: Nanoengineered Particles for Enhanced Intra‐Articular Retention and Delivery of Proteins (Adv. Healthcare Mater. 10/2014)

Abstract

Localized intra‐articular delivery of anti‐inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of rapid clearance within few hours of injection. On page 1562, A. J. García and co‐workers report a new class of polymer that forms self‐assembled nanoparticles with therapeutic proteins for prolonged retention in intra‐articular joint spaces compared to bolus protein doses.