The orphan G protein-coupled receptor 25 (GPR25) is activated by Apelin and Apela in non-mammalian vertebrates

Zhang, Jiannan; Wan, Ying; Fang, Chao; Chen, Junan; Ouyang, Wangan; Li, Juan; Wang, Yajun

doi:10.1016/j.bbrc.2018.04.229

Cited by 12 publications

(8 citation statements)

References 24 publications

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“…Only four members of the MMPs (MMP-1, MMP-8, MMP-13 and MT1-MMP) can degrade fibrillar collagens in their triple-helical domain which leave the molecules thermally unstable so that they unwind to form gelatine after which they can be degraded by other members of the MMP family. However, MT1-MMP is also able to degrade gelatine [ 56 ]. Due to the fact that we observed the effect of apelin treatment on proteolytic activities in FITC-conjugated gelatine assay and in gastric cancer cell lines where apelin treatment stimulated the protein level of MMPs [ 21 ], we visualised MT1-MMP-membrane-anchored MMP using immunocytochemistry.…”

Section: Discussionmentioning

confidence: 99%

“…Since Tatemoto et al found apelin as a ligand for orphan APLNR [ 4 ], several mechanisms including signalling pathways were examined [ 7 ]. The latest data indicated that the orphan G protein-coupled receptor 25 also could be activated by apelin in non-mammalian vertebrates [ 56 ]. This new finding suggests that orphan receptors could be still potentially activated by apelin.…”

Section: Discussionmentioning

confidence: 99%

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Apelin Effects Migration and Invasion Abilities of Colon Cancer Cells

Podgórska

Pietraszek-Gremplewicz

Nowak

2018

Cells

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Colon cancer is one of the most common cancer types. Its positive correlation with general obesity has led to increasing amounts of research focusing on the role of adipokines in colon cancer development. Apelin is a peptide released by adipose tissue that could affect many cellular processes connected with carcinogenesis. In this study, we examined the role of apelin in the motility regulation of colon cancer cells. We showed that the effect of four different apelin peptides increased the ability of cancer cells to migrate and invade examined cells trough influencing migratory protrusions formation and actin cytoskeleton rearrangement. Additionally, using confocal microscopy, we noticed that apelin stimulated the proteolytic activity of cancer cells, especially increasing the level of membrane-type 1 matrix metalloprotease. Taken together, apelin increased the movement of colon cancer cells through several possible mechanisms. Moreover, better understanding the process through which apelin regulates cancer development is still necessary to the creation of novel anti-cancer therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Apelin Effects Migration and Invasion Abilities of Colon Cancer Cells

Podgórska

Pietraszek-Gremplewicz

Nowak

2018

Cells

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“…Similar to APLN, APELA binds to APLNR, subsequently activating G α i/o and G α -q/11 mediated signaling cascades, including PI3K/Akt, PKC and PKC-independent Ras/MAPK pathways ( Fig. 2A ) ( Perjés et al, 2016 ; Zhang et al, 2018 ). Nevertheless, it also plays non-redundant role for its specific properties during embryo development.…”

Section: Apln and Apela Endogenous Ligands Of Aplnrmentioning

confidence: 99%

Emerging roles of APLN and APELA in the physiology and pathology of the female reproductive system

Liu

Song

Shen

et al. 2020

PeerJ

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APLN, APELA and their common receptor APLNR (composing the apelinergic axis) have been described in various species with extensive body distribution and multiple physiological functions. Recent studies have witnessed emerging intracellular cascades triggered by APLN and APELA which play crucial roles in female reproductive organs, including hypothalamus-pituitary-gonadal axis, ovary, oviduct, uterus and placenta. However, a comprehensive summary of APLN and APELA roles in physiology and pathology of female reproductive system has not been reported to date. In this review, we aim to concentrate on the general characteristics of APLN and APELA, as well as their specific physiological roles in female reproductive system. Meanwhile, the pathological contexts of apelinergic axis dysregulation in the obstetrics and gynecology are also summarized here, suggesting its potential prospect as a diagnostic biomarker and/or therapeutic intervention in the polycystic ovary syndrome, ovarian cancer, preeclampsia and gestational diabetes mellitus.

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“…Similar to APLN, APELA binds to APLNR, subsequently activating Gαi/o and Gαq/11 mediated signaling cascades, including PI3K/Akt, PKC and PKC-independent Ras/MAPK pathways (Fig 2 A) (Perjés et al, 2016;Zhang et al, 2018). Nevertheless, it also plays non-redundant role for its specific properties during embryo development.…”

Section: Apela Dependent Signaling Pathwaymentioning

confidence: 99%

Peer Review #1 of "Emerging roles of APLN and APELA in the physiology and pathology of the female reproductive system (v0.1)"

2020

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The orphan G protein-coupled receptor 25 (GPR25) is activated by Apelin and Apela in non-mammalian vertebrates

Cited by 12 publications

References 24 publications

Apelin Effects Migration and Invasion Abilities of Colon Cancer Cells

Apelin Effects Migration and Invasion Abilities of Colon Cancer Cells

Emerging roles of APLN and APELA in the physiology and pathology of the female reproductive system

Peer Review #1 of "Emerging roles of APLN and APELA in the physiology and pathology of the female reproductive system (v0.1)"

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