Zeolitic
imidazolate framework-8 (ZIF-8) nanoparticles are able
to act as effective reinforcements to enhance the overall performance
of a poly-l-lactic acid (PLLA) scaffold due to its interface
compatibility and natural degradability. Nevertheless, the fast degradation
of ZIF-8 would release excessive zinc ions, which produces adverse
effects on natural cell growth. In this study, a core–shell-structured
nanoparticle, in which ZIF served as a core and hydroxyapatite (HA)
served as a shell, was constructed by polydopamine (PDA)-induced in
situ growth of HA on ZIF-8 nanoparticles, aiming to control the zinc
ion release. Then, the core–shell-structured nanoparticle (ZIF-8@PDA-HA)
was introduced into the PLLA scaffold using selective laser sintering.
Results showed that the zinc ion concentration for the PLLA/ZIF-8@PDA-HA
scaffold decreased by 65.3% after 28 days of immersion, as compared
with the PLLA/ZIF-8 scaffold. Moreover, the in situ-synthesized HA
possessed superior bioactivity, which effectively enhanced the mineralization
ability of scaffolds and promoted cell adhesion, proliferation, and
differentiation.
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