Surface modification enhances interfacial bonding in PLLA/MgO bone scaffold

Shuai, Cijun; Zan, Jun; Peng, Shuping; Yang, Wenjing; Qi, Fangwei; Shen, Lida; Tian, Zongjun

doi:10.1016/j.msec.2019.110486

Cited by 46 publications

(26 citation statements)

References 57 publications

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“…Using stem cell self‐renewal and differentiation ability to treat osteoporosis may be the most potential way of bone repair, which is expected to solve the medical problems of bone regeneration and repair 29 . In recent years, biological scaffolds have made rapid progress 30‐33 . It is particularly urgent to clarify the mechanism of stem cell differentiation and develop new strategies to induce stem cell differentiation.…”

Section: Discussionmentioning

confidence: 99%

Linc02349 promotes osteogenesis of human umbilical cord‐derived stem cells by acting as a competing endogenous RNA for miR‐25‐3p and miR‐33b‐5p

et al. 2020

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Objectives: Increasing evidences suggest that inducing mesenchymal stem cells to differentiate into osteoblasts has been as an especially important component in the prevention and therapy for degenerative bone disease. Here, we identify a novel lncRNA, linc02349, which increases significantly during osteogenic differentiation. Materials and methods:Human umbilical cord-derived stem cells (hUC-MSCs) and dental pulp mesenchymal stem cells were used. Overexpression and knockdown of linc02349 in cell lines were generated using lentiviral-mediated gene delivery method.Bioinformatics prediction, Ago2-RIP assay and dual-luciferase reporter system were employed to examine miRNA which interacts with linc02349. The RNA FISH assay was performed to identify the subcelluar location of linc02349. Alizarin Red S staining, ALP staining and qPCR were applied to identify the osteogenic differentiation. The potential linc02349-regulated genes, miR-25-3p and miR-33b-5p, were explored by ChIP, RIP and Western blotting assays. Micro-CT was used to measure the osteogenic content in bone formation assay in vivo. Results: Linc02349 overexpression improves osteogenic differentiation by in vitroand in vivo analysis. Mechanistically, linc02349 acts as a molecular sponge for miR-25-3p and miR-33b-5p to control expression abundance of SMAD5 and Wnt10b,

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Section: Discussionmentioning

confidence: 99%

Linc02349 promotes osteogenesis of human umbilical cord‐derived stem cells by acting as a competing endogenous RNA for miR‐25‐3p and miR‐33b‐5p

et al. 2020

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“…Additive manufacturing (AM) technology has currently gained intensive attention for fabricating synthetic bone scaffolds as orthopedics implants [5][6][7][8][9]. Unlike the conventional material removal processes, AM involves a whole host of 'bottom up' approaches, which creates three dimensional objects originated from computerdesigned models by gradually building them up with a layer-by-layer method [10,11].…”

Section: Introductionmentioning

confidence: 99%

Selective laser melted Fe-Mn bone scaffold: microstructure, corrosion behavior and cell response

Shuai

Yang

et al. 2020

Mater. Res. Express

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Iron metal possesses good biocompatibility and excellent mechanical strength, though it degrades too slowly. In this work, selective laser melting (SLM) was applied to fabricate iron-manganese (Fe-Mn) biodegradable scaffold. Results shown Fe-Mn scaffold exhibited a uniform pore structure with a porosity of 66.72±2.3%, which highly matched with as-designed model. Phase analysis revealed Fe-Mn scaffold mainly contained α-Fe, martensitic and austenitic phases. Due to the potential difference among these different phases, galvanic corrosion occurred in Fe matrix. In addition, a small amount of Mn distributed at grain boundaries also contributed to the formation of galvanic corrosion. Thus, the corrosion rate increased from 0.09±0.02 mm/year to 0.23±0.05 mm/year. The scaffold exhibited suitable mechanical properties with a yield strength of 137±8.4 MPa, an ultimate strength of 221.7±10.9 MPa. Moreover, cell assays demonstrated its good cytocompatibility. Taking these positive results into consideration, SLM processed Fe-Mn scaffold was a promising material for bone repair application.

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“…However, they found it was difficult to form good interfacial bonding in metal matrix composite due to the large physical and chemical differences between the matrix and the reinforcing phase [21][22][23][24]. This will reduce the load transfer capacity of the enhancement phase [25][26][27][28]. Hence, it is imperative to get better interfacial bonding between the Zn matrix and the reinforcements to improve the mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

In situ decomposition of Ti₂AlN promoted interfacial bonding in ZnAl-Ti₂AlN biocomposites for bone repair

Shuai

Xue

Gao

et al. 2020

Mater. Res. Express

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In this study, in situ decomposition of Ti 2 AlN was used to obtain strong interfacial bonding in Zn7Al-Ti 2 AlN composites prepared via laser melting. During the preparation process, the Al atoms in Ti 2 AlN could diffuse out of the lattice due to the weak bonding between Al and Ti, followed by easily diffusing into the liquid Zn7Al matrix. Consequently, the diffused Al could bond with the Al in Zn7Al matrix owing to their inherent chemical affinity, leading to a strong interfacial bonding in Zn7Al-Ti 2 AlN composites. This significantly improved the load transfer ability and prohibited the motion of dislocations in the composites. As a result, the hardness and compressive strength of Zn7Al-Ti 2 AlN composites were enhanced from 74 HV and 155 MPa to 80 HV and 205 MPa, respectively, which were more suitable for bone repair application. What's more, the composites also showed improved accelerated degradation and cytocompatibility.

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Surface modification enhances interfacial bonding in PLLA/MgO bone scaffold

Cited by 46 publications

References 57 publications

Linc02349 promotes osteogenesis of human umbilical cord‐derived stem cells by acting as a competing endogenous RNA for miR‐25‐3p and miR‐33b‐5p

Linc02349 promotes osteogenesis of human umbilical cord‐derived stem cells by acting as a competing endogenous RNA for miR‐25‐3p and miR‐33b‐5p

Selective laser melted Fe-Mn bone scaffold: microstructure, corrosion behavior and cell response

In situ decomposition of Ti₂AlN promoted interfacial bonding in ZnAl-Ti₂AlN biocomposites for bone repair

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Surface modification enhances interfacial bonding in PLLA/MgO bone scaffold

Cited by 46 publications

References 57 publications

Linc02349 promotes osteogenesis of human umbilical cord‐derived stem cells by acting as a competing endogenous RNA for miR‐25‐3p and miR‐33b‐5p

Linc02349 promotes osteogenesis of human umbilical cord‐derived stem cells by acting as a competing endogenous RNA for miR‐25‐3p and miR‐33b‐5p

Selective laser melted Fe-Mn bone scaffold: microstructure, corrosion behavior and cell response

In situ decomposition of Ti2AlN promoted interfacial bonding in ZnAl-Ti2AlN biocomposites for bone repair

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Product

Resources

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In situ decomposition of Ti₂AlN promoted interfacial bonding in ZnAl-Ti₂AlN biocomposites for bone repair