Selective laser melted Fe-Mn bone scaffold: microstructure, corrosion behavior and cell response

Abstract

Iron metal possesses good biocompatibility and excellent mechanical strength, though it degrades too slowly. In this work, selective laser melting (SLM) was applied to fabricate iron-manganese (Fe-Mn) biodegradable scaffold. Results shown Fe-Mn scaffold exhibited a uniform pore structure with a porosity of 66.72±2.3%, which highly matched with as-designed model. Phase analysis revealed Fe-Mn scaffold mainly contained α-Fe, martensitic and austenitic phases. Due to the potential difference among these different phases, galvanic corrosion occurred in Fe matrix. In addition, a small amount of Mn distributed at grain boundaries also contributed to the formation of galvanic corrosion. Thus, the corrosion rate increased from 0.09±0.02 mm/year to 0.23±0.05 mm/year. The scaffold exhibited suitable mechanical properties with a yield strength of 137±8.4 MPa, an ultimate strength of 221.7±10.9 MPa. Moreover, cell assays demonstrated its good cytocompatibility. Taking these positive results into consideration, SLM processed Fe-Mn scaffold was a promising material for bone repair application.

Linc02349 promotes osteogenesis of human umbilical cord‐derived stem cells by acting as a competing endogenous RNA for miR‐25‐3p and miR‐33b‐5p

“…Using stem cell self‐renewal and differentiation ability to treat osteoporosis may be the most potential way of bone repair, which is expected to solve the medical problems of bone regeneration and repair 29 . In recent years, biological scaffolds have made rapid progress 30‐33 . It is particularly urgent to clarify the mechanism of stem cell differentiation and develop new strategies to induce stem cell differentiation.…”

Development of AM Technologies for Metals in the Sector of Medical Implants

“…Fe-Mn alloy has been used to produce bone scaffolds by SLM [88]. Mn is added to control the high degradation of Fe.…”

In situ decomposition of Ti2AlN promoted interfacial bonding in ZnAl-Ti2AlN biocomposites for bone repair

“…Zn alloys are introduced as a new class of bio absorbable metals for biomedical application owing to their good biocompatibility as well as nearly ideal biodegradation rate [1][2][3][4][5]. In terms of biocompatibility, as an abundant element in the human body, Zn plays a vital role in cell proliferation and the metabolism of human body [6][7][8][9].…”