nMgO-incorporated PLLA bone scaffolds: Enhanced crystallinity and neutralized acidic products

Shuai, Cijun; Zan, Jun; Qi, Fangwei; Wang, Guoyong; Liu, Zheng; Peng, Shuping

doi:10.1016/j.matdes.2019.107801

Cited by 64 publications

(38 citation statements)

References 40 publications

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“…Such a high level of process flexibility enable it can directly fabricate complex internal structures and customized shapes. Up to now, AM has been applied to prepare bone scaffolds from various materials, including metals [12][13][14], polymers [15][16][17] and ceramics [18][19][20], even their composites [21][22][23]. Among them, metal bone scaffolds are most promising for load-bearing bone repair [24].…”

Section: Introductionmentioning

confidence: 99%

Selective laser melted Fe-Mn bone scaffold: microstructure, corrosion behavior and cell response

Shuai

Yang

et al. 2020

Mater. Res. Express

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Iron metal possesses good biocompatibility and excellent mechanical strength, though it degrades too slowly. In this work, selective laser melting (SLM) was applied to fabricate iron-manganese (Fe-Mn) biodegradable scaffold. Results shown Fe-Mn scaffold exhibited a uniform pore structure with a porosity of 66.72±2.3%, which highly matched with as-designed model. Phase analysis revealed Fe-Mn scaffold mainly contained α-Fe, martensitic and austenitic phases. Due to the potential difference among these different phases, galvanic corrosion occurred in Fe matrix. In addition, a small amount of Mn distributed at grain boundaries also contributed to the formation of galvanic corrosion. Thus, the corrosion rate increased from 0.09±0.02 mm/year to 0.23±0.05 mm/year. The scaffold exhibited suitable mechanical properties with a yield strength of 137±8.4 MPa, an ultimate strength of 221.7±10.9 MPa. Moreover, cell assays demonstrated its good cytocompatibility. Taking these positive results into consideration, SLM processed Fe-Mn scaffold was a promising material for bone repair application.

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Section: Introductionmentioning

confidence: 99%

Selective laser melted Fe-Mn bone scaffold: microstructure, corrosion behavior and cell response

Shuai

Yang

et al. 2020

Mater. Res. Express

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“…In spite of not having surfaces with contact angles values between 40–70°, which is considered the range for better cell adhesion as it has been reported, the obtained scaffolds should not be ruled out. The last because there are additional factors that affect the wettability of the material, such as the presence of surface groups, as well as the roughness of the material that contributes to said characteristic …”

Section: Resultsmentioning

confidence: 99%

“…The last because there are additional factors that affect the wettability of the material, such as the presence of surface groups, as well as the roughness of the material that contributes to said characteristic. [28][29][30] Also, the structure and porosity of the scaffold play an important role in cell growth, and therefore, these parameters have been evaluated in cell cultures. The porosity of the material also is reported in Table 1 and as it can be observed, all the supports exhibit porosity higher than 95%, which is the recommended percentage by various authors.…”

Section: Characterization Of Materials and Supportmentioning

confidence: 99%

Influence of RGD Peptide on Morphology and Biocompatibility of 3D Scaffolds Based on PLA/Hydroxyapatite

et al. 2019

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The developments of three‐dimensional and bioactive supports are essential for bone tissue engineering. Therefore, this study reports the morphology and biological behavior of osteoblast cells grown on bioactive 3D scaffolds, obtained by electro‐spinning and based on poly(lactic acid), PLA, and Hydroxyapatite, HAp, composites (PLA/HAp), which were superficially treated with RGD. Likewise, the characterization of the obtained 3D scaffolds is presented and discussed. The results indicate that it is possible to obtain structures with porosities higher than 90% with interconnected channels, which favor cell adhesion and growth. Also, the biological performance evaluation of the scaffolds indicates that surface treatment with RGD was effective and has a synergistic effect along with HAp. The cell adhesion was also observed by SEM and the images show cells extended and adhered to the scaffold's fibers along with neighboring cells. Also, the HAp had an influence on cell proliferation, which showed the maximum values with 2.5 and 5.0% wt of HAp. Therefore, 3D PLA/HAp scaffolds, obtained by electrospinning, treated with RGD represent promising material for use in bone tissue engineering.

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Section: Introductionmentioning

confidence: 99%

“…Magnesium (Mg) alloys are potential biomedical implant materials for orthopedic applications on account of their unique biodegradability and excellent mechanical properties. [1][2][3][4][5][6][7][8][9][10][11] However, the very fast degradation rate of Mg alloys greatly restricts their application. [12][13][14][15] It is crucial to develop Mg alloys with satisfactory degradation resistance.…”

Section: Introductionmentioning

confidence: 99%

Mn‐promoting formation of a long‐period stacking‐ordered phase in laser‐melted Mg alloys to enhance degradation resistance

Shuai

Liu

Gao

et al. 2019

Materials & Corrosion

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Magnesium (Mg) alloys are promising candidates for use as biomedical implant materials. However, their very fast degradation rate greatly restricts their application. A rare earth phase possessed with a long‐period stacking‐ordered (LPSO) structure was in favor of enhancing the degradation resistance of Mg alloys. In fact, the formation of the LPSO phase in Mg alloys depends on their stacking fault energy. The lower the stacking fault energy, the more the LPSO phase formed. In this study, manganese (Mn) was alloyed to Mg alloy ZK30–10Gd (containing 3 wt.% Zn and 10 wt.% Gd) via selective laser melting to promote the formation of the LPSO phase. As an alloying element, Mn could be in favor of reducing stacking fault energy due to the fact that the large difference between the atomic radius of Mn and that of Mg induced large lattice distortion to facilitate forming stacking faults. The results showed that as the Mn content increased from 0 to 1.2 wt.%, the area fraction of LPSO phase increased from 12.22% to 22.37%, meanwhile the area fraction of (Mg,Zn)3Gd phase decreased from 9.31% to 2.32%. The ZK30–10Gd–0.6Mn possessed the highest degradation resistance (weight loss rate 0.38 mg · cm−2 · day−1). The enhancement of degradation resistance had two reasons. On the one hand, more LPSO phase provided more sites for nucleation of degradation products, which could promote the formation of a homogeneous and compact degradation product film to protect the Mg matrix. On the other hand, the inhibition of (Mg,Zn)3Gd phase precipitation could reduce galvanic corrosion.

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nMgO-incorporated PLLA bone scaffolds: Enhanced crystallinity and neutralized acidic products

Cited by 64 publications

References 40 publications

Selective laser melted Fe-Mn bone scaffold: microstructure, corrosion behavior and cell response

Selective laser melted Fe-Mn bone scaffold: microstructure, corrosion behavior and cell response

Influence of RGD Peptide on Morphology and Biocompatibility of 3D Scaffolds Based on PLA/Hydroxyapatite

Mn‐promoting formation of a long‐period stacking‐ordered phase in laser‐melted Mg alloys to enhance degradation resistance

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