This study provides information on the behavior of macrophages on the surface of the subcutaneously implanted hydrogel strips. Hydrogel containing -OH, -CO-NH-, and (CH3)2N- groups induced a spreading of macrophages on the implants. The materials containing -SO3H groups slightly, and materials containing -COOH groups more intensively, inhibited spreading of the macrophages. The fusion of macrophages into multinucleate cells was inhibited on the surface of materials containing acidic groups (-SO3H, -COOH) and increased on the hydrogels containing 30 mol% of alkaline (CH3)2N- groups in comparison with hydrogels containing -OH or -CO -NH- groups. The differences of the behavior of macrophages on the surface of individual types of hydrogels are probably independent on the adsorption of plasma fibronectin onto the hydrogels. The correlation between the macrophages spreading and fusion and surface charge of the hydrogel implant can be hypothetically explained by electrostatic interaction between macrophages cell membrane and implant.
A strip of partially hydrolyzed poly (2-hydroxyethyl methacrylate) containing 65%-75% H2O was implanted into the anterior eye chamber of 11 Chinchilla rabbits. No pathological changes were found in the iris or in the ciliary body. The pathological findings in the cornea accompanying implantation of a hydrogel strip to the anterior chamber were rare and not significant. The low occurrence of the foreign body giant multinucleate cells was observed on the implant surface 6 months after the implantation. Favorable properties of this hydrogel depend probably on its high water and acidic groups content.
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