Intraocular biocompatibility of hydroxyethyl methacrylate and methacrylic acid copolymer/partially hydrolyzed poly(2‐hydroxyethyl methacrylate)

Smetana, Karel; Šulc, Jiří; Krčová, Zuzana; Pitrová, S

doi:10.1002/jbm.820211007

Cited by 30 publications

(11 citation statements)

References 8 publications

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“…17 In biocompatibility studies of subcutaneously and intraocularly implanted PHEMA sponges, there is no or minimal local tissue inflammation over weeks to months. 73 There is modest cell invasion by fibroblasts and capillaries into the implant for soft tissue replacement, 9 whereas sponge implants into the spinal cord and for optic nerve injuries are invaded by glial cells and ED1 ϩ macrophage cells. 67 A minority of the long-term but not the short-term implants have demonstrated microcalcification.…”

Section: Biomaterials Considerationsmentioning

confidence: 99%

Growth factor enhancement of peripheral nerve regeneration through a novel synthetic hydrogel tube

Midha¹,

Munro²,

Dalton³

et al. 2003

Journal of Neurosurgery

178

102

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Section: Biomaterials Considerationsmentioning

confidence: 99%

Growth factor enhancement of peripheral nerve regeneration through a novel synthetic hydrogel tube

Midha¹,

Munro²,

Dalton³

et al. 2003

Journal of Neurosurgery

178

102

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“…For use in medical applications like iris implants, the dyes and the corresponding polymers have to be biocompatible (ISO 11979-5) [33–35]. To analyze the photosensitivity of the materials, the dye-containing polymers were preserved in a sodium chloride solution at 35 °C and exposed to irradiation with visible light (3 mW/cm 2 2500 h) for 100 days.…”

Section: Resultsmentioning

confidence: 99%

Polymerization of novel methacrylated anthraquinone dyes

Dollendorf

Kreth²,

Choi³

et al. 2013

Beilstein J. Org. Chem.

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SummaryA new series of polymerizable methacrylated anthraquinone dyes has been synthesized by nucleophilic aromatic substitution reactions and subsequent methacrylation. Thereby, green 5,8-bis(4-(2-methacryloxyethyl)phenylamino)-1,4-dihydroxyanthraquinone (2), blue 1,4-bis(4-((2-methacryloxyethyl)oxy)phenylamino)anthraquinone (6) and red 1-((2-methacryloxy-1,1-dimethylethyl)amino)anthraquinone (12), as well as 1-((1,3-dimethacryloxy-2-methylpropan-2-yl)amino)anthraquinone (15) were obtained. By mixing of these brilliant dyes in different ratios and concentrations, a broad color spectrum can be generated. After methacrylation, the monomeric dyes can be covalently emplaced into several copolymers. Due to two polymerizable functionalities, they can act as cross-linking agents. Thus, diffusion out of the polymer can be avoided, which increases the physiological compatibility and makes the dyes promising compounds for medical applications, such as iris implants.

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“…Poly(N-vinyl-2-pyrrolidone) (PVP) and related hydrogels are studied for versatile applications in biomedicine, biotechnology and a vast field where the controlled release of chemicals is required [1][2][3][4][5][6] . Highly crosslinked PVP hydrogels are generally prepared from the monomer, with or without some comonomers, in the presence of a crosslinking agent 7) .…”

Section: Introductionmentioning

confidence: 99%

The effect of external stimuli on the invertase adsorption capacity of poly(N-vinyl-2-pyrrolidone-co-itaconic acid) hydrogels

Tümtürk¹,

̧aykara²,

Kantoğlu³

et al. 1999

Angew. Makromol. Chem.

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Polyelectrolyte Poly(N-vinyl-2-pyrrolidone-co-itaconic acid) hydrogels (P(VP/IA)) with varying compositions were prepared from ternary VP/IA/water mixtures. The effect of external stimuli such as pH of the solution, temperature, substrate concentration of solution, and storage stability on the invertase adsorption capacity of P(VP/IA) hydrogels was investigated. The adsorption capacity of the hydrogels was found to increase from 4.4 to 18.4 mg invertase/g dry gel with increasing amount of IA in the gel system, while P(VP) gel adsorbed only 3.1 mg invertase/g dry gel. Kinetic parameters were calculated as Michaelis-Menten constant K m = 20.6 mmol L -1 and maximum velocity V max = 6.44610 -5 mol dm -3 min -1 for free enzyme and in the range of K m = 26.4 -41.1 mmol L -1 and V max = 6.35 N 10 -5 -6.66 N 10 -5 mol dm -3 min -1 , depending on the amount of IA in the hydrogel. Enzyme activities were found to increase from 59.0% to 72.0% with increasing amount of IA in the gel system and retained their activities for one month storage. The enzyme activities, after storage for one month at 4 8C, were found to be 21.0% and 59.0 -74.0% of the initial activity values for free and adsorbed enzyme, respectively. The optimal pH values for free and adsorbed enzymes were determined as 4.56 and 5.00, respectively. The optimum temperature for free and adsorbed enzymes was 55 8C. Adsorption studies have shown that not only the gel composition but also the stimuli, temperature and pH of the solution play an important role on the invertase adsorption capacity of poly(VP/IA) hydrogels.ZUSAMMENFASSUNG: Aus ternären Mischungen von N-Vinyl-2-pyrrolidon (VP)/Itaconsäure(IA)/Wasser wurden Poly(VP/IA)-Hydrogel-Polyelektrolyte unterschiedlicher Zusammensetzung hergestellt. Der Einfluß äußerer Bedingungen wie dem pH-Wert der Lösung, der Temperatur, der Substratkonzentration der Lösung oder der Lagerstabilität auf die Invertaseadsorptionskapazität der P(VP/IA)-Hydrogele wurde untersucht. Die Adsorptionskapazität der Hydrogele steigt mit wachsendem IA-Anteil im Gelsystem von 4,4 auf 18,4 mg Invertase/g trockenen Gels, während PVP-Gel nur 3,1 mg Invertase/g trockenen Gels adsorbiert. Die kinetischen Parameter für das freie und das adsorbierte Enzym wurden berechnet. Für das freie Enzym wurden die Michaelis-Menten-Konstante K m = 20,6 mmol L -1 und maximale Geschwindigkeit V max = 6,44 N 10 -5 mol dm -3 min -1 erhalten, die Werte für das adsorbierte Enzym lagen im Bereich von K m = 26,4 -41,1 mmol L -1 und V max = 6,35 N 10 -5 -6,66 N 10 -5 mol dm -3 min -1 in Abhängigkeit vom IA-Anteil im Hydrogel. Die Enzymaktivitäten erhöhten sich mit steigendem IA-Anteil im Gelsystem von 59,0% auf 72,0% und blieben auch bei einmonatiger Lagerung stabil. Die Enzymaktivitäten nach einmonatiger Lagerung bei 4 8C betrugen 21,0% und 59,0 -74,0% der ursprünglichen Werte für freies und adsorbiertes Enzym. Die optimalen pH-Werte für das freie und das adsorbierte Enzym sind 4,56 bzw. 5,00, die günstigste Temperatur ist in beiden Fällen 55 8C. Adsorptionsuntersuchungen...

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Intraocular biocompatibility of hydroxyethyl methacrylate and methacrylic acid copolymer/partially hydrolyzed poly(2‐hydroxyethyl methacrylate)

Cited by 30 publications

References 8 publications

Growth factor enhancement of peripheral nerve regeneration through a novel synthetic hydrogel tube

Growth factor enhancement of peripheral nerve regeneration through a novel synthetic hydrogel tube

Polymerization of novel methacrylated anthraquinone dyes

The effect of external stimuli on the invertase adsorption capacity of poly(N-vinyl-2-pyrrolidone-co-itaconic acid) hydrogels

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