Silicone rubber-hydrogel composites as polymeric biomaterials

Lopour, P.; Vondráček, Petr; Janatová, V.; Šulc, Jiří; Vacı́k, J.

doi:10.1016/0142-9612(90)90094-7

Cited by 34 publications

(20 citation statements)

References 5 publications

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“…The results of morphological study obtained are in agreement with the assumption [3] that the transport of low-molecular weight watersoluble substances in water-swollen composite materials occurs by communication between single swollen particles and aggregates of hydrogel polymer. The existence of voids (gaps, microcracks) between swollen particles of the hydrogel and matrix was not confirmed.…”

Section: Study Of the Structure By Optical Microscopy And Scanning Elsupporting

confidence: 87%

“…The swelling of the hydrogel-filled silicone rubber composite is determined by the content and swelling capacity of the hydrophilic filler. By using a poly(HEMA-co-MAA) filler, it is possible to prepare composites which can take up 90 wt% of water [3]. The copolymer is a typical ionogenic material and the swelling is pH dependent.…”

Section: Swelling and Mechanical Propertiesmentioning

confidence: 99%

“…Contact angles of silicone rubber-poly(HEMA) [3] and silicone rubber-poly(HEMA-co-MAA) [7] were measured. Contact angles of silicone rubber-poly(HEMA) [3] and silicone rubber-poly(HEMA-co-MAA) [7] were measured.…”

Section: Hydrophilicitymentioning

confidence: 99%

“…Concerning the application of composite materials silicone rubberhydrogel for the controlled drug release and as reservoir layers for the transdermal forms of drugs, transport properties of these composite materials were measured for several water-soluble, low-molecular com-pounds of both ionic and nonionic nature, including some drugs [3,8]. It was found that the composite materials silicone rubber-poly(HEMAco-MAA) containing more than 50 wt% water exhibits considerable permeability for these compounds.…”

Section: Permeability Of Low-molecular Water-soluble Compoundsmentioning

confidence: 99%

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Silicone Rubber-Hydrogel Composites as Biomaterials

Vondráček¹,

Lopour

Šulc

1991

Journal of Bioactive and Compatible Polymers

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Heyrovského nám. 2 162 06 Prague 6 Czechoslovakia ABSTRACT: This report surveys the recent preparations and properties of hydrophilic elastomeric composite materials consisting of a matrix from silicone rubber and a hydrogel filler. The reader will find a description of preparation methods for these materials and their various properties, such as mechanical, swelling, biological, transport, and surface properties, which are important for a potential use in medical and-pharmaceutical applications. The results of a microscopical study of the composite structure are also included.

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Section: Study Of the Structure By Optical Microscopy And Scanning Elsupporting

confidence: 87%

Section: Swelling and Mechanical Propertiesmentioning

confidence: 99%

Section: Hydrophilicitymentioning

confidence: 99%

Section: Permeability Of Low-molecular Water-soluble Compoundsmentioning

confidence: 99%

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Silicone Rubber-Hydrogel Composites as Biomaterials

Vondráček¹,

Lopour

Šulc

1991

Journal of Bioactive and Compatible Polymers

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“…Applications of PHEMA are versatile and it has been engaged in injectable polymeric systems, nasal cartilage, ophthalmic applications, drug delivery systems, artificial corneas and wound dressings [16][17][18][19][20]. There are many reports in the literature for improving the surface properties of silicone using hydrogels by laser, plasma, corona discharge and particulate composites methods [21][22][23][24][25][26][27]. Another option for modifying PDMS by hydrogels is to form an interpenetrating polymer network [28][29][30][31] .…”

mentioning

confidence: 99%

Grafting of collagen onto interpenetrating polymer networks of poly(2-hydroxyethyl methacrylate) and poly(dimethyl siloxane) polymer films for biomedical applications

Rezaei¹,

Ishak²

2014

Express Polym. Lett.

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Poly(dimethyl siloxane) (PDMS) films were modified using poly(2-hydroxyethyl methacrylate) (PHEMA) by sequential method of interpenetrating polymer networks (IPNs). Collagen (type I) was also linked onto the modified films via methyl sulfonyl chloride. Collagen reacted with the activated groups to obtain covalently linked protein layers. The surface properties of samples were characterised by attenuated total reflectance Fourier transform infrared spectroscopy (ATRFTIR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and water contact angle measurements. Dynamic Mechanical Thermoanalysis (DMTA) and tensile testing were used to study the physical and mechanical properties of the IPNs. Grafting of collagen on the surface was confirmed using ATR-FTIR and XPS. The results also showed that the hydrophilicity of modified samples increased as the content of PHEMA increased. The biocompatibility of the PDMS surface was evaluated by culture of fibroblast cells (L929). The collagen-linked surfaces showed significant cell adhesion and growth in comparison with unmodified PDMS samples

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Synthesis and properties of powdery hydrogels based on acrylamide, methacrylamide, and their N‐substituted derivatives

Lopour

Ševčík

Labský

et al. 1996

Angew. Makromol. Chem.

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Lightly crosslinked hydrogels based on acrylamide, N-( 1,l -dimethyl-3-oxobutyl)acrylamide, N,N-dimethylacrylamide, methacrylamide, N-(2-hydroxypropyl)methacrylamide and N-[tris(hydroxymethyl)methyl]methacrylamide were synthesized in form of fine powders, consisting of aggregates of very small (-lo-' pm) particles. The powdery hydrogels were obtained by precipitation polymerization in acetone and diethyl ether, using N,N'-methylenebisacrylamide and ethylene dimethacrylate as crosslinking agents. Dependences of water-swellability, particle size, aggregation, specific surface and content of the uncrosslinked water-soluble polymers and lowmolecular-weight substances in the hydrogels on the conditions of their synthesis were studied. Suitability of particular powdery hydrogels synthesized for the preparation of silicone rubberhydrogel composites is discussed. ZUSAMMENFASSUNG:Leicht vernetzte Hydrogele auf der Basis von Acrylamid, N-( l,l-Dimethy1-3-0~0butyl)acrylamid, N,N-Dimethylacrylamid, Methacrylamid, N-(2-Hydroxypropyl)methacrylamid und N-[Tris(hydroxymethyl)methyl]methacrylamid wurden in Form von pulverigen Substanzen synthetisiert, die aus Aggregaten sehr kleiner Partikel (-lo-' pm) bestehen. Die pulverartigen Hydrogele wurden durch Fdlungspolymerisation in Aceton und Diethylether unter Verwendung von N,N'-Methylenbisacrylamid und Ethylendimethacrylat als Vernetzungsmittel synthetisiert. Es wurden die Abhiingigkeiten des Quellungsgrades in Wasser, der GroBe, des Aggregationsgrades und der spezifischen Oberflache von Partikeln, und des Inhalts von wasserloslichen Substanzen in den Hydrogelen von den Bedingungen ihrer Synthese verfolgt. Die Eignung einzelner der synthetisierten Hydrogele fur die Herstellung von Silikonkautschuk-Hydrogel-Kompositen wird diskutiert.

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Silicone rubber-hydrogel composites as polymeric biomaterials

Cited by 34 publications

References 5 publications

Silicone Rubber-Hydrogel Composites as Biomaterials

Silicone Rubber-Hydrogel Composites as Biomaterials

Grafting of collagen onto interpenetrating polymer networks of poly(2-hydroxyethyl methacrylate) and poly(dimethyl siloxane) polymer films for biomedical applications

Synthesis and properties of powdery hydrogels based on acrylamide, methacrylamide, and their N‐substituted derivatives

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