Copper(I)-catalyzed alkyne−azide cycloaddition (CuAAC) is a resourceful and stereospecific methodology that has considerably yielded promising 1,2,3-triazole-appended "click" scaffolds with the potential for selective metal ion recognition. Based on "click" methodology, this report presents a chemosensor probe (TCT) based on 4-tert-butylcatechol architecture, via the CuAAC pathway, as a selective and efficient sensor for Pb(II) and Hg(II) ions, categorized as the most toxic and alarming environmental contaminants among the heavy metal ions. The synthesized probe was successfully characterized by spectroscopy [IR and NMR ( 1 H and 13 C)] and mass spectrometry. The chemosensing study performed in acetonitrile/water (4:1) solvent media, via UV−vis and fluorescence spectroscopy, established its selective sensitivity for Pb(II) and Hg(II) species among the list of explored metal ions with the limits of detection being 8.6 and 11 μM, respectively. Additionally, the 1 H NMR and IR spectra of the synthesized TCT−metal complex also confirmed the metal− ligand binding. Besides, the effect of time and temperature on the binding ability of TCT with Pb(II) and Hg(II) was also studied via UV−vis spectroscopy. Furthermore, density functional theory studies put forward the structural comprehension of the sensor by availing the hybrid density functional (B3LYP)/6311G++(d,p) basis set of theory which was subsequently utilized for investigating its anti-inflammatory potential by performing docking analysis with human leukotriene b4 protein.
Organosilicon chemistry is appraised as the trunk of coalescence and structural manoeuvre of moieties. Schiff base compounds are popular auxiliary scaffolds having vast applications in the fields of biological activities,...
A new set of morpholine analogue Schiff base linked organosilanes(5a-5c) was prepared. The prepared compounds were characterized by (1H and 13C) NMR and mass spectrometry. The sensing ability of receptor...
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