Bis-triazole with indole pendant Organosilicon framework: Probe for recognition of Pb2+ ions

Singh, Gurjaspreet; Satija, Pinky; Singh, Akshpreet; Pawan, -; Mohit, .; Kaur, Jashan Deep; Devi, Anita; Saini, Anamika; Singh, Jandeep

doi:10.1016/j.molstruc.2021.129963

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…Above and beyond, the probe was structurally optimized via density functional theory (DFT) using the hybrid density functional (B3LYP)/6311G++(d, p) basis set of theory and subsequently docked with human leukotriene b4 to ascertain its anti-inflammatory effects. Although the literature is abundant with 1,2,3-triazole-based chemosensors for Pb(II) and Hg(II) sensing either distinctly − or in addition to some other metal ions such as Fe 3+ , Cu 2+ , Zn 2+ , and so forth, − this is the first report, to the best of our knowledge, wherein a single 1,2,3-triazole-appended ligand is a potential recognition agent for concomitant sensing of Pb(II) and Hg(II).…”

Section: Introductionmentioning

confidence: 99%

CuAAC-Derived Selective Fluorescent Probe as a Recognition Agent for Pb(II) and Hg(II): DFT and Docking Studies

et al. 2022

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Copper(I)-catalyzed alkyne−azide cycloaddition (CuAAC) is a resourceful and stereospecific methodology that has considerably yielded promising 1,2,3-triazole-appended "click" scaffolds with the potential for selective metal ion recognition. Based on "click" methodology, this report presents a chemosensor probe (TCT) based on 4-tert-butylcatechol architecture, via the CuAAC pathway, as a selective and efficient sensor for Pb(II) and Hg(II) ions, categorized as the most toxic and alarming environmental contaminants among the heavy metal ions. The synthesized probe was successfully characterized by spectroscopy [IR and NMR ( 1 H and 13 C)] and mass spectrometry. The chemosensing study performed in acetonitrile/water (4:1) solvent media, via UV−vis and fluorescence spectroscopy, established its selective sensitivity for Pb(II) and Hg(II) species among the list of explored metal ions with the limits of detection being 8.6 and 11 μM, respectively. Additionally, the 1 H NMR and IR spectra of the synthesized TCT−metal complex also confirmed the metal− ligand binding. Besides, the effect of time and temperature on the binding ability of TCT with Pb(II) and Hg(II) was also studied via UV−vis spectroscopy. Furthermore, density functional theory studies put forward the structural comprehension of the sensor by availing the hybrid density functional (B3LYP)/6311G++(d,p) basis set of theory which was subsequently utilized for investigating its anti-inflammatory potential by performing docking analysis with human leukotriene b4 protein.

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Section: Introductionmentioning

confidence: 99%

CuAAC-Derived Selective Fluorescent Probe as a Recognition Agent for Pb(II) and Hg(II): DFT and Docking Studies

et al. 2022

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“…1,2,3-Triazoles are a rising class of heterocyclic compounds that have received significant attentiveness from the past few years because of their versatile applications in biochemical, pharmaceutical, sensing and material sciences. [1][2][3][4][5][6][7] The copper (I) catalyzed synthesis of 1,2,3-triazoles from azides and terminal alkynes is an increasingly common method for rapid synthesis of organic and bioorganic compounds in high yields and purity. [8][9][10][11] Therefore, the well recognized click route was followed to generate 1,2,3-triazole derivatives.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Antioxidant Biphenyl Appended 1,2,3‐Triazoles as Potential Chemo‐Sensor for Sn²⁺ Ions: Excellent Selectivity and Low Detection Limit

et al. 2021

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Designing of chemo-sensors is a new scope of intrigue among researchers. After inspecting the beneficial and harmful effects of Sn(II) metal ions in living species, 1,2,3-Triazole based chemo-sensor 4 a have been synthesized via click route. In the current article, literarily new 1,2,3-Triazoles (4 a-4 d) have been synthesized and identified via various spectroscopic means such as NMR( 1 H & 13 C), IR and mass spectrometry. Triazole 4 a was explored for recognition properties via absorption and emission spectroscopy and found specific and selective for Sn(II) metal ions. The recognition of Sn 2 + metal ions by probe 4a was not interfered because of other tested metal cations. The probe has very low detection limit of 0.47 × 10 À 7 M and 3.8 × 10 À 9 M via ultraviolet and fluorescence spectroscopy respectively which is lower than many previously reported sensors. The BÀ H plot and stern volmer's plot confirmed a high binding affinity between probe 4a and tin (II) metal ion. The association constant (K a ) and stern volmer constant (K sv ) were calculated as 13.36 × 10 5 M À 1 and 12.6 × 10 6 M À 1 from BÀ H plot and stern volmer's plot respectively. The Stoichiometric ratio between chemo-sensor 4 a and Sn 2 + metal ions was confirmed as 1 : 1 by the job's plot. Moreover, in this study, the synthesized compounds 4(a-d) were examined for their antioxidant properties. The total antioxidant activity (TAA) results indicate that the synthesized triazoles 4(a-d) found to be excellent postulant for radical scavenging. TAA values for 4 a, 4 b, 4 c and 4 d are found to be 4.65 � 0.2, 6.79 � 0.3, 6.29 � 0.2, 5.06 � 0.1 (mM)(eq. ascorbic acid) per 100 mM of particle respectively.

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“…This probe is made up of indole crown and Schiff's base. It is used to identify the lead ion in the solution21 . carboxaldehyde reacts with BA and TBA in the presence of ethanol to form a chemo sensor as a product under reflux conditions.…”

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Fluorescent and Colorimetric Chemosensor for the Detection of Toxic Metal Ions of Mercury and Lead – A Mini Review

Tamizselvi¹,

Napoleon²

2022

ECS Trans.

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Variations in the predictable level of heavy metals ions have an uncompromising influence on living being and their surroundings. Real sample analysis was used to identify the heavy metal ions by using colorimetric and fluorescence techniques. The interaction of metal ions with the receptor has produced observable signals as measured by its photophysical changes. Nitrogen-containing heterocyclic compounds are the greatest weapons for identifying heavy metal ions, owing to their diverse reactivity, readily available substrate, and exquisite photophysical property. The main goal of this mini-review is to examine the current advancements in the structural analysis of nitrogen-containing heterocyclic compound-based fluorescence and colorimetric sensors. The interaction between receptor and metal by electron transfer mechanism and its wide applications have been developed and used for the sensing of heavy metal ions in the past ten years by various research groups about selectivity, sensitivity, reversibility, pH effect, stoichiometric ratio, binding constant, LOD values, and real-time applications.

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Bis-triazole with indole pendant Organosilicon framework: Probe for recognition of Pb2+ ions

Cited by 7 publications

References 31 publications

CuAAC-Derived Selective Fluorescent Probe as a Recognition Agent for Pb(II) and Hg(II): DFT and Docking Studies

CuAAC-Derived Selective Fluorescent Probe as a Recognition Agent for Pb(II) and Hg(II): DFT and Docking Studies

Synthesis and Characterization of Antioxidant Biphenyl Appended 1,2,3‐Triazoles as Potential Chemo‐Sensor for Sn²⁺ Ions: Excellent Selectivity and Low Detection Limit

Fluorescent and Colorimetric Chemosensor for the Detection of Toxic Metal Ions of Mercury and Lead – A Mini Review

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Bis-triazole with indole pendant Organosilicon framework: Probe for recognition of Pb2+ ions

Cited by 7 publications

References 31 publications

CuAAC-Derived Selective Fluorescent Probe as a Recognition Agent for Pb(II) and Hg(II): DFT and Docking Studies

CuAAC-Derived Selective Fluorescent Probe as a Recognition Agent for Pb(II) and Hg(II): DFT and Docking Studies

Synthesis and Characterization of Antioxidant Biphenyl Appended 1,2,3‐Triazoles as Potential Chemo‐Sensor for Sn2+ Ions: Excellent Selectivity and Low Detection Limit

Fluorescent and Colorimetric Chemosensor for the Detection of Toxic Metal Ions of Mercury and Lead – A Mini Review

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Product

Resources

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Synthesis and Characterization of Antioxidant Biphenyl Appended 1,2,3‐Triazoles as Potential Chemo‐Sensor for Sn²⁺ Ions: Excellent Selectivity and Low Detection Limit