In the extensive terrain of catalytic procedures for the synthesis of organic molecules, metal–organic frameworks (MOFs) as heterogenous catalysts have been investigated in a variety of chemical processes, including Friedel–Crafts reactions, condensation reactions, oxidations, and coupling reactions, and utilized owing to their specific properties such as high porosity, tuneability, extraordinary catalytic activity, and recyclability. The eminent copper-tailored MOF materials can be exceptionally dynamic and regioselective catalysts for click reactions (1,3-dipolar cycloaddition reaction). Considering the fact that Cu(I)-catalyzed alkyne–azide cycloaddition (CuAAC) reactions can be catalyzed by several other copper catalysts such as Cu (II)-β-cyclodextrin, Cu(OAc)2, Fe3O4@SiO2, picolinimidoamide–Cu(II) complex, and Cu(II) porphyrin graphene, the properties of sorption and reusability, as well as the high density of copper-MOFs, open an efficient and robust pathway for regimented catalysis of this reaction. This review provides a comprehensive description and analysis of the relevant literature on the utilization of Cu-MOFs as catalysts for CuAAC ‘click’ reactions published in the past decade.
Copper(i) catalyzed alkyne azide cycloaddition is the quintessential example of ‘Click Chemistry’, provides an adaptable platform for the synthesis of nanogels for sustained drug release at targeted sites owing to their better biocompatibility.
Among azoles, tetrazoles are a class of heterocycles that have salient applications in almost every field of science. Organosilicon chemistry is pondering amalgamate of different moieties and has vast applications....
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