Synthesis, “turn-on” fluorescence signals towards Zn<sup>2+</sup> and Hg<sup>2+</sup> and monoamine oxidase A inhibitory activity using a molecular docking approach of morpholine analogue Schiff base linked organosilanes

Singh, Gurjaspreet; Devi, Anita; Mohit, .; Diksha, .; Suman, .; Saini, Anamika; Kaur, Jashan Deep; Gupta, Sofia; Vikas, .

doi:10.1039/d2nj03767j

Cited by 7 publications

(2 citation statements)

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“…[24,25] Silanes find extensive use across multiple domains, including corrosion prevention, flame retardants, hydrophobic agents, corrosion prevention, organic synthesis and medicinal chemistry. [26,27] The fusion of silanes and Schiff bases provides structural flexibility and the nitrogen and oxygen atoms bearing lone-pairs of electrons can interact with the ions. [28] Considering these parameters, we have aimed at the synthesis of ether derived Schiff-base allied silanes for the detection of Cr(III) via UV-visible spectroscopy.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

Singh,

Thakur,

Priyanka

et al. 2024

ChemistrySelect

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Chromium is known to play an important role in various metabolic pathways; however, its excessive use can result in negative impact on mankind, this necessitates the development of sensors for Cr(III) ion. The current study has incorporated the synthesis of ether derived Schiff base allied silanes 4 a–4 d, which have been characterized using 1H NMR, 13C NMR and mass spectrometry. The spectroscopic technique of UV‐visible has been utilized to study the sensing behaviour of probe 4 a, resulting in a good sensing ability towards Cr(III) ion, yielding a detection limit of 4.2×10−7 M and an association constant value of 2.25×106 M−1. In order to study the stoichiometric binding between probe and metal ion, Job's plot method has been employed which shows 1 : 1 binding ratio. The mechanism of binding has been studied via 1H NMR, UV‐visible, FT‐IR spectroscopy and mass spectrometry. The binding has been further supported by DFT. The real sample analysis has been performed to validate the utility of the synthesized sensor in practical applications. The theoretical tool of molecular docking has been considered to study the protein‐ligand interaction between S. aureus bacterial protein and ligand 4 a, yielding a value of −7.63 kcal/mol for binding energy.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

Singh,

Thakur,

Priyanka

et al. 2024

ChemistrySelect

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“…[43] Now-a-days organosilanes, have grasped the attention of researchers in field of qualitative and quantitative detection. [44] Many hybrid structures of organosilanes with triazoles have been reported, most of them being used as metal ion sensors, [45,46] but none of them was investigated as sensor of anions. In the present work, an attempt has been made to prepare hybrid structure comprising of triazole and organosilane.…”

Section: Introductionmentioning

confidence: 99%

Click‐Generated Triazole‐Based Silanes: A Potent Chemosensor for Dihydrogen Phosphate

et al. 2023

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Over the years, ground and surface water has been reported to be contaminated with phosphates. These phosphates are known to cause various diseases and if present in excess can lead to eutrophication. The known silane chemistry has not been thoroughly investigated for the sensing of anions. In the current study four new triazole based silanes have been prepared by the renowned Click Chemistry for the selective and sensitive detection of dihydrogen phosphate. The synthesized compounds were well characterized by various spectroscopic techniques and their absorptive and emissive responses were investigated for the recognition of dihydrogen phosphate ions. The binding ratio between triazole based silane chemosensor and dihydrogen phosphate has been discovered from Job's plot and was also confirmed by non‐linear fitting method. The value of association constant was found to be 571.18 M−1. The limit of detection (LOD) and limit of quantitation (LOQ) were calculated by fluorescence spectroscopy. The results obtained clearly illustrated that triazole based silane could be used as a potent chemosensor for selective and sensitive recognition of dihydrogen phosphate. Further, the possible binding site of chemosensor for dihydrogen phosphate has been identified from 1H NMR studies and DFT calculations. At last real sample analysis was performed to check the practical applicability of chemosensor.

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1,2,3-triazole hybrid organosilanes: Synthesis, photophysical detection of F- ions and molecular docking

Singh

Devi

Diksha

et al. 2023

Inorganic Chemistry Communications

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Synthesis, “turn-on” fluorescence signals towards Zn²⁺ and Hg²⁺ and monoamine oxidase A inhibitory activity using a molecular docking approach of morpholine analogue Schiff base linked organosilanes

Abstract: A new set of morpholine analogue Schiff base linked organosilanes(5a-5c) was prepared. The prepared compounds were characterized by (1H and 13C) NMR and mass spectrometry. The sensing ability of receptor...

Cited by 7 publications

References 46 publications

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

Click‐Generated Triazole‐Based Silanes: A Potent Chemosensor for Dihydrogen Phosphate

1,2,3-triazole hybrid organosilanes: Synthesis, photophysical detection of F- ions and molecular docking

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Synthesis, “turn-on” fluorescence signals towards Zn2+ and Hg2+ and monoamine oxidase A inhibitory activity using a molecular docking approach of morpholine analogue Schiff base linked organosilanes

Abstract: A new set of morpholine analogue Schiff base linked organosilanes(5a-5c) was prepared. The prepared compounds were characterized by (1H and 13C) NMR and mass spectrometry. The sensing ability of receptor...

Cited by 7 publications

References 46 publications

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

Click‐Generated Triazole‐Based Silanes: A Potent Chemosensor for Dihydrogen Phosphate

1,2,3-triazole hybrid organosilanes: Synthesis, photophysical detection of F- ions and molecular docking

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Synthesis, “turn-on” fluorescence signals towards Zn²⁺ and Hg²⁺ and monoamine oxidase A inhibitory activity using a molecular docking approach of morpholine analogue Schiff base linked organosilanes