No abstract

As compared to gel and other topical preparations microemulgel has been prepared by screening of oils, emulsifier, and co-emulsifier on bases of solubility of an API in it. An API has high solubility and oil may also have more or less pharmacological property, so it may assist the therapeutic action of API. Due to presence of oil portion, it leads to more penetration of API in the skin. Oil Micelle Size was less than 500 nm which provides more area for absorption of API in the skin so more penetration and more effective than macro-emulsion. Microemulgel has an advantage of emulgel that has dual benefits of micro-emulsion and gel and several other desirable properties like good consistency, thyrotrophic, greaseless, easily spreadable as well as removable, emollient, non-staining, water soluble, longer shelf-life, bio-friendly, transparent, pleasant appearance, ability of patients for self-medication, termination of medications will be easy, etc.

No abstract

39 refs.]. -(ASHARA, K. C.; PAUN, J. S.; SONIWALA, M. M.; CHAVADA, J. R.; MORI, N. M.; Asian Pac. J. Trop. Dis. 4 (2014) Suppl. 1, S27-S32, http://dx.

As because of several advantages over to the conventional drug delivery Nanosparticulate drug delivery prepared in several means by several ways of methods have several applications in different discipline of Pharmaceutical science. There are various parameters for Evaluation of Nanoparticles as Drug Delivery system so we can justified as nanoparticulate drug delivery system: a novel approach.

Background: Fluconazole and ketoconazole both have poor minimum inhibitory concentration than voriconazole. Voriconazole had serious side eff ects in oral and intravenous doses. It has poor water solubility. The objective of the study was to prepare and optimize microemulgel of voriconazole for topical delivery. Aim: Formulation, development, and evaluation of voriconazole microemulgel for topical delivery. Methods: Oil and emulsifi ers selected were on the basis of equilibrium solubility study and emulsifi cation property respectively. The pseudo-ternary plot and constrained simplex lattice design were applied for preparation of microemulsions. Microemulsions were subjected to micelle size, zeta potential, polydispersity index, and in vitro study. They were optimized by Design-Expert ® 9.0.3.1 software. Formulation, development, evaluation and optimization of microemulgel were carried out. Microbial assay of an optimized batch of microemulgel was performed.

The brain is a delicate organ and nature has very efficiently protected it. Brain is protected by presence of two barrier systems BBB (Blood Brain Barrier) and BCSFB (Blood Cerebrospinal Fluid Barrier) from very harmful materials. Despite aggressive research, patients suffering from fatal or debilitatingcentral nervous system (CNS) diseases, such as brain tumours, HIV encephalopathy, epilepsy, cerebrovascular diseases and neurodegenerative disorders, clinical failure of it restricts the passive diffusion of many drugs into the brain and constitutes a significant obstacle in pharmacological treatment of CNS disorders. Various strategies like non-invasive methods, including drug manipulation encompassing transformation into lipophilic analogues, pro-drugs, chemical mediated, carrier-mediated, vector mediated and intranasal mediated drug delivery. 'SLN technology based therapy' made available a novel and sound platform for therapeutics. Solid lipid nanoparticles (SLNs) are structured for a novel system to provide drugs for removal of unwanted actions by modified formulations and for organ/cell targeting of moieties. Appropriate analytical techniques for the characterization of SLN is described hear. This article contains method of preparation, utilization of excipients(s), uses and highlighting of various approaches and meritsof SLN for brain targeting drug delivery as colloidal drug carriers.

No abstract