Micro-emulsion based emulgel: a novel topical drug delivery system

Ashara, Kalpesh Chhotalal; Paun, Jalpa S.; Soniwala, Moinuddin; Chavada, J. R.; Mori, Nitin Merubhai

doi:10.1016/s2222-1808(14)60411-4

Cited by 64 publications

(48 citation statements)

References 18 publications

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“…1% aqueous dilution of Emulgel and the marketed cream Onabet TM was done by adding Continuous phase and visually checked for phase separation and clarity [11].…”

Section: Dilution Testmentioning

confidence: 99%

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Development and Evaluation of Tioconazole Loaded Emulgel

2017

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Objective: The objective of the present work was to develop, characterize and evaluate the tioconazole loaded emulgel and to prove that emulgel can be the best alternative for delivery of hydrophobic drug topically.Methods: for the preparation of stable Emulgel, firstly gels were prepared using different polymers as carbopol 934 and xanthan gum, followed by preparation of emulsions and finally mixed together (table 1). Emulgel was evaluated for physical appearance, pH, spreadability, extrudability, viscosity, swelling index, dilution test, centrifuge test, drug content, in vitro release study, kinetic analysis of release data, antifungal activity and stability study for 3 mo. A comparative study was also performed between prepared emulgels with available marketed antifungal cream.Results: All evaluation parameters were in acceptable range with good physical appearance and the pH in the range of 5.5 to 6.8. The results show that the extrudability was in the range 15.63 to 35.27 g/cm 2 ; with spreadability in range of 6.6 to 8.833 cm. swelling index of F3 was seen a maximum in 3 h of about 75.13%. The viscosity was in the range of 15240 to 56340 cps at 10 RPM. During in vitro release of all formulations, F1 and F5 showed a maximum in vitro drug release of 59.11% and 55.11% respectively in 8 h. The kinetic analysis of fitting the data in different model shows that the best formulation of F1 fits in the Higuchi model with regression coefficient (R 2 ) of 0.998 and show non-fickian diffusion. The formulations were found stable. F1 and F5 provide a similar zone of inhibition like to market cream. Conclusion:Tioconazole emulgel provide the better platform for delivery of hydrophobic drug for topical route and so able to produce better patient compliance.

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“…1% aqueous dilution of Emulgel and the marketed cream Onabet TM was done by adding Continuous phase and visually checked for phase separation and clarity [11].…”

Section: Dilution Testmentioning

confidence: 99%

“…All prepared formulations and marketed cream were diluted with water and result indicated no phase separation upon dilution [11].…”

Section: Dilution Testmentioning

confidence: 99%

Development and Evaluation of Tioconazole Loaded Emulgel

2017

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“…On the other hand, drug solubility guarantees content uniformity of dosage form which is important for topical delivery that intrinsically suffers from erratic and unpredictable drug absorption. [32][33][34] Therefore, investigation on the selection of proper solvent for formulation of TDDSs which simultaneously provides adequate drug solubility and appropriate skin penetration would be invaluable. Therefore, the aim of the present study was to investigate the effects of different vehicles on the solubility and transdermal delivery of Tadalafil.…”

Section: -28mentioning

confidence: 99%

The Relationship between Solubility and Transdermal Absorption of Tadalafil

et al. 2015

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“…In spite of many advantages of gels which enhance dissolution of drugs, and increases migration of the drug in comparison with the ointment or cream base a major restraint of gel is in the transfer of hydrophobic drugs e. g piroxicam and mefenamic acid. So to overcome this problem, emulgels are prepared and used so that a hydrophobic moiety can exhibit the advantages of gels [1][2][3]. Emulsions are the systems of two or more immiscible liquid phases.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Release, Rheology and Stability of Piroxicam Emulgel

2018

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Objective: The purpose of this work was to develop and optimize the emulgel formulation of piroxicam with two types of gelling agent chitosan and xanthan gum. The release profiles of prepared formulas were investigated. In addition, the rheology and stability of the best formula were investigated. Methods:Emulsified piroxicam was prepared to use oleic acid, tween 80 and PG with a ratio (3:10:10). In xanthan based emulgel, the xanthan gum (1% and 1.5%) was spread as powder on emulsified piroxicam with stirring until emulgel was formed. In chitosan-based emgels, Chitosan gel was added to emulsified piroxicam and stirring until the Emulgel was constructed. Chitosan gels were prepared by incorporating different concentration, 2%, 3%, 6% w/v of chitosan in 1% v/v of glacial acetic acid in distilled water. In vitro release of piroxicam from different formulas was conducted in 300 ml phosphate buffer pH 7.4, at a speed of 120 rpm at 37±2°C. The amount of the drug released from the bases was determined spectrophotometrically at 504 nm. Viscometer Myr. Vr 3000 was used to measure the viscosity of the prepared formulas. The prepared formulas were stored in well-stoppered polyvinyl chloride (PVC) plastic containers in the dark for 6 mo at room temperature. They were checked for drug content, viscosity, and pH change bimonthly throughout the period. Results:The results showed that the dissolution increases significantly with increasing the concentration of xanthan. Chitosan has significant synergized the enhancements of xanthan gum in the release. Rheological behaviour of the selected formula containing chitosan (2%) and xanthan gum (1.5) had shear thinning in nature showing a decrease in viscosity at the increasing shear rates. The selected formula was stable 6 mo at 40˚C/75% RH and 4˚C. The formula found was yellow viscous creamy preparation with the smooth homogenous appearance. The pH and the drug release was also found to be stable under storage conditions. Conclusion:Piroxicam release can be improved by preparing emulgel which stable and have good rheologic properties.

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Micro-emulsion based emulgel: a novel topical drug delivery system

Cited by 64 publications

References 18 publications

Development and Evaluation of Tioconazole Loaded Emulgel

Development and Evaluation of Tioconazole Loaded Emulgel

The Relationship between Solubility and Transdermal Absorption of Tadalafil

Preparation, Release, Rheology and Stability of Piroxicam Emulgel

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