Development and Evaluation of Tioconazole Loaded Emulgel

Abstract

Objective: The objective of the present work was to develop, characterize and evaluate the tioconazole loaded emulgel and to prove that emulgel can be the best alternative for delivery of hydrophobic drug topically.Methods: for the preparation of stable Emulgel, firstly gels were prepared using different polymers as carbopol 934 and xanthan gum, followed by preparation of emulsions and finally mixed together (table 1). Emulgel was evaluated for physical appearance, pH, spreadability, extrudability, viscosity, swelling index, dilution test, centrifuge test, drug content, in vitro release study, kinetic analysis of release data, antifungal activity and stability study for 3 mo. A comparative study was also performed between prepared emulgels with available marketed antifungal cream.Results: All evaluation parameters were in acceptable range with good physical appearance and the pH in the range of 5.5 to 6.8. The results show that the extrudability was in the range 15.63 to 35.27 g/cm 2 ; with spreadability in range of 6.6 to 8.833 cm. swelling index of F3 was seen a maximum in 3 h of about 75.13%. The viscosity was in the range of 15240 to 56340 cps at 10 RPM. During in vitro release of all formulations, F1 and F5 showed a maximum in vitro drug release of 59.11% and 55.11% respectively in 8 h. The kinetic analysis of fitting the data in different model shows that the best formulation of F1 fits in the Higuchi model with regression coefficient (R 2 ) of 0.998 and show non-fickian diffusion. The formulations were found stable. F1 and F5 provide a similar zone of inhibition like to market cream. Conclusion:Tioconazole emulgel provide the better platform for delivery of hydrophobic drug for topical route and so able to produce better patient compliance.

Characterisation of Novel Topical Olive Oil Oleohydrogel Hybrid for Controlled Drug Release

“…Evaluation of applicability parameters [13][14] Applicability parameters for topical preparation include determination of extrudibility and spreadability. Extrudibility of native oleogels and oleohydrogel hybrids was studied by filling the formulation into a collapsible tube followed by measuring the distance travelled by the ribbon of extruded gel in 10s (Eq.…”

“…The hypothesis of the thermocycling stability study (freeze-thaw) is that the gelator / gelator-co-gelator layer, which is primarily a surfactant, may get damaged due to the change in the physicochemical properties thereby leading to the instability of the formulations when subjected to frequent temperature changes. 13 This study helps to predict the mechanism of destabilization of the formulations due to the change in the physicochemical properties at the extreme conditions. The chances of oxidative changes are predominant at higher temperatures whereas the formation of solidified structures at lower temperatures may alter the physical interactions amongst the sample components responsible for the formation of the networked structures.…”

“…Similar observation was reported by Shah et al in his work on olive oil based Span 40 and Span 60 organogels. 13 FTIR analysis of olive oil based oleogels and oleohydrogel hybrids thus indicate compatibility between the oil, organogelator, surfactant and drug.…”

Comparative Study of Span 40 and Span 60 Based Soy-Gels for Topical Drug Delivery

“…A fixed weight of organogel was filled into an ointment tube and crimped. The extrudability (cm/s) of gel was determined by measuring the length of the gel ribbon extruded from the ointment tube by applying uniform pressure over a period of 10 s [19]. The following equation was used to determine extrudability.…”

Micellar Microparticles: A Novel Approach to Topical Drug Delivery System

“…The TDDS includes large variety of pharmaceutical dosage form like liquid preparations, semisolids and spray powders. However, the most widely used semisolid preparation for topical drug delivery includes gels, creams and ointments [2]. Topical formulations are applied to the superficial areas such as the skin, eyes, nose and vagina for the treatment of local diseases [3].…”