Microemulgel of Voriconazole: an Unfathomable Protection to Counter Fungal Contagiousness

Abstract

Background: Fluconazole and ketoconazole both have poor minimum inhibitory concentration than voriconazole. Voriconazole had serious side eff ects in oral and intravenous doses. It has poor water solubility. The objective of the study was to prepare and optimize microemulgel of voriconazole for topical delivery. Aim: Formulation, development, and evaluation of voriconazole microemulgel for topical delivery. Methods: Oil and emulsifi ers selected were on the basis of equilibrium solubility study and emulsifi cation property respectively. The pseudo-ternary plot and constrained simplex lattice design were applied for preparation of microemulsions. Microemulsions were subjected to micelle size, zeta potential, polydispersity index, and in vitro study. They were optimized by Design-Expert ® 9.0.3.1 software. Formulation, development, evaluation and optimization of microemulgel were carried out. Microbial assay of an optimized batch of microemulgel was performed.

Nanoparticles: A Novel Antifungal Drug Delivery System

“…For skin and transdermal medication organization, these are straightforward, stable, and isotropic scatterings of oil in water settled by surfactants and co-surfactants with drop sizes of 0.1-1.0 m. Because of their exceptional ability to increment drug dissolvability, these have been reported to be extremely encouraging conveyance frameworks and hostile to parasitic specialists [22]. Due to their low aqueous solubility, many azole drugs' antifungal spectra are compromised.…”

Recent advances in topical carriers of anti-fungal agents

“…In a recent study by Ashara and co-workers determined the solubility of voriconazole in a microemulsion system developed by using Neem oil Acrysol™K-150 and PEG as oil phase, surfactant and co-surfactant respectively. Results indicated the solubility of voriconazole in Neem® oil microemulsion was found to be 7.51 ± 0.14 mg/g against 2.7 ± 0.12 mg/g of plain drug characterized by a significant increase in MIC values [ 74 ].…”