Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
One of the most popular applications of nanotechnology in both topical and internal medicine administration to the body is nanogel technology. The materials comprising the nanoparticulate frameworks are less than 100 nm in a single measurement. The goal of this review paper is to provide a concise overview of the most recent developments in the nanogel medicine delivery framework with regard to drug loading and swelling. It categorises according to links (chemical and physical) and responding behaviour. This article is to give a broad overview of nanogels, their innovative use in many contexts, and current synthesis techniques. NGs use drugs for a variety of reasons, including diagnostics, gene targeting, organ targeting, and many more. Different pulmonary, nasal, transdermal, intra-ocular, oral, and parenteral routes can be used to give NGs. The primary goals of this review are to present broad details on NGs, their characteristics, multiple categories, medication targeting strategies, kinds of drug delivery systems, assessment techniques, and cutting-edge uses for NGs in depth. Keywords: Nanogel, DLS, CD, mechanism of drug release, classification, application
One of the most popular applications of nanotechnology in both topical and internal medicine administration to the body is nanogel technology. The materials comprising the nanoparticulate frameworks are less than 100 nm in a single measurement. The goal of this review paper is to provide a concise overview of the most recent developments in the nanogel medicine delivery framework with regard to drug loading and swelling. It categorises according to links (chemical and physical) and responding behaviour. This article is to give a broad overview of nanogels, their innovative use in many contexts, and current synthesis techniques. NGs use drugs for a variety of reasons, including diagnostics, gene targeting, organ targeting, and many more. Different pulmonary, nasal, transdermal, intra-ocular, oral, and parenteral routes can be used to give NGs. The primary goals of this review are to present broad details on NGs, their characteristics, multiple categories, medication targeting strategies, kinds of drug delivery systems, assessment techniques, and cutting-edge uses for NGs in depth. Keywords: Nanogel, DLS, CD, mechanism of drug release, classification, application
Background: Antifungal resistance (AFR) is a global public health problem with devastating effects, especially among immunocompromised individuals. Addressing AFR requires a One Health approach including Antifungal Stewardship (AFS). This study aimed to comprehensively review global studies published on fungal infections and AFR and to recommend solutions to address this growing problem. Materials and Methods: This was a narrative review that was conducted using published papers on fungal infections, AFR, and AFS between January 1961 and March 2024. The literature was searched using PubMed, Google Scholar, Web of Science, and EMBASE. Results: This found that there has been an increase in fungal infections globally, especially among immunocompromised patients. Due to this increase in fungal infections, there has been a proportionate increase in the use of antifungal agents to prevent and treat fungal infections. This increased use of antifungal agents has worsened the problem of AFR contributing to increased morbidity and mortality. Globally, fungal infections have contributed to 150 million infections annually and 1.7 million deaths per year. By the year 2023, over 3.8 million people died from fungal infections. Addressing AFR remains a challenge because the treatment of antifungal-resistant infections is difficult. Finally, the treatment of fungal infections is a global challenge exacerbated by the limited number of antifungal agents to treat invasive fungal infections. Conclusion: The results of this study indicated that fungal infections and AFR are prevalent across humans, animals, agriculture, and the environment. Addressing this problem requires the provision of solutions such as improving the awareness of AFR, conducting further research on the discovery of new antifungal agents, and implementing AFS programs. If this global problem is not addressed, the morbidity and mortality associated with AFR will continue to rise in the future.How to cite this paper: Mudenda, S.
Study’s Novelty/Excerpt This study comprehensively review the significant advancements in the antimicrobial application of silver nanoparticles (AgNPs), focusing on innovative delivery mechanisms such as nanogels, liposomes, and polymer-based nanoparticles. It highlights the unique physicochemical properties of AgNPs that contribute to their antibacterial efficacy, including their ability to disrupt bacterial cell membranes and inhibit biofilm formation. The review also addresses the critical challenges of cytotoxicity and delivery method refinement, emphasizing the potential of AgNPs in combating antibiotic-resistant bacteria. Full Abstract Nanoparticles,especially silver nanoparticles (AgNPs), have revolutionized various fields like microbiology, biotechnology, pharmacy, and medicine owing to their distinct properties. This research delves into the significant potential of AgNPs in antimicrobial therapy, focusing on recent advancements in their delivery mechanisms, mechanisms of action, and antibacterial efficacy. The effective targeted delivery of AgNPs to specific body sites remains a challenge, leading to innovative approaches in nanotechnology. Nanogels, liposomes, and polymer-based nanoparticles have emerged as promising delivery systems, enhancing the stability, bioavailability, and controlled release of AgNPs. The antimicrobial activity of AgNPs is rooted in their unique physicochemical properties, such as high surface area and reactivity. They disrupt bacterial cell membranes, increasing permeability, causing cell death, and interfering with intracellular components. Additionally, AgNPs have shown potential in inhibiting biofilm formation, a common defense mechanism of bacteria against antibiotics. Despite their promise, addressing issues related to cytotoxicity and refining delivery methods remains imperative. This review comprehensively addresses the challenges associated with the delivery of AgNPs, their cytotoxic effects, and their efficacy against antibiotic-resistant bacteria, highlighting their mechanism of action in bacterial eradication and biofilm inhibition.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.