Recent advances in topical carriers of anti-fungal agents

Garg, Abhinava; Sharma, Ganti S.; Goyal, Amit K.; Ghosh, Goutam; Chandra, Sudam; Rath, Goutam

doi:10.1016/j.heliyon.2020.e04663

Cited by 61 publications

(49 citation statements)

References 116 publications

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“…Empirical experience shows that conventional topical preparations suffer from certain limitations and are compromised in patient compliance, safety, and efficacy of therapy [62]. Against this background, the need for advanced carriers that could effectively improve skin penetration and reduce drug-related side effects is more than necessary [63].…”

Section: Retinoidsmentioning

confidence: 99%

Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders

Stefanov

Andonova

2021

Pharmaceuticals

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The multifunctional role of the human skin is well known. It acts as a sensory and immune organ that protects the human body from harmful environmental impacts such as chemical, mechanical, and physical threats, reduces UV radiation effects, prevents moisture loss, and helps thermoregulation. In this regard, skin disorders related to skin integrity require adequate treatment. Lipid nanoparticles (LN) are recognized as promising drug delivery systems (DDS) in treating skin disorders. Solid lipid nanoparticles (SLN) together with nanostructured lipid carriers (NLC) exhibit excellent tolerability as these are produced from physiological and biodegradable lipids. Moreover, LN applied to the skin can improve stability, drug targeting, occlusion, penetration enhancement, and increased skin hydration compared with other drug nanocarriers. Furthermore, the features of LN can be enhanced by inclusion in suitable bases such as creams, ointments, gels (i.e., hydrogel, emulgel, bigel), lotions, etc. This review focuses on recent developments in lipid nanoparticle systems and their application to treating skin diseases. We point out and consider the reasons for their creation, pay attention to their advantages and disadvantages, list the main production techniques for obtaining them, and examine the place assigned to them in solving the problems caused by skin disorders.

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Section: Retinoidsmentioning

confidence: 99%

Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders

Stefanov

Andonova

2021

Pharmaceuticals

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“…Fungal biofilms are often studied using the microtiter plate paradigm. Morphogenetic alterations, growth circumstances, cell density, and the kind of extracellular matrix connections all influence biofilm development in Candida albicans [27,28]. As the biofilm develops, the entire process is carefully regulated and managed by a sophisticated regulatory network.…”

Section: Antifungal Medication Resistance and Biofilm Formationmentioning

confidence: 99%

A Review on SLN and NLC for Management of Fungal Infections

Ramu

Spandana

Divith

et al. 2021

JPRI

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Fungal disease is an invasive, serious, and systemic topical infection that affects the mucous membranes, tissues, and skin of humans. Oral medicines, on the other hand, have significant side effects, making topical treatments a viable alternative. Many antifungal medications applied through the skin in various conventional forms (gels or creams) may cause skin redness, erythema, stinging, and burning sensations. A promising approach to overcome the limitation of conventional form is the use of Nanocarriers for the treatment of skin infections since it allows targeted drug delivery, enhanced skin permeability, and controlled release and hence offers a lower risk of side effects. During the last few decades, lipid nanoparticles (LNPs) such as solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have gained a lot of attention. SLNs were designed to overcome the drawbacks of conventional colloidal carriers, such as emulsions, liposomes, and polymeric nanoparticles, by offering benefits such as a good release rate and drug targeting with high physical stability. NLCs are SLNs that have been modified (Second generation SLN) to improve stability and capacity loading. This review discusses the pathophysiology of the fungal diseases, the application of SLN and NLC, its method of preparation, Characterization, and an overview of clinical trials on SLN and NLC for the treatment of fungal infection.

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“…It is well known that skin is an important body barrier towards external chemical, mechanical, physical, and microbial stresses, resulting in a protection against pathogens and water loss [ 1 , 2 , 3 ]. Notwithstanding these important functions, skin may be affected by many problematic disorders (e.g., rashes), infections of different nature (i.e., viral, bacterial, fungal, and parasitic), injuries caused by cuts or burns, and tumors [ 4 , 5 , 6 , 7 ]. The treatment of skin disorders can be done with topical applications of drugs on the action site.…”

Section: Introductionmentioning

confidence: 99%

Lipid-Based Nanosystems as a Tool to Overcome Skin Barrier

Sguizzato

Esposito

Cortesi

2021

IJMS

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Skin may be affected by many disorders that can be treated by topical applications of drugs on the action site. With the advent of nanotechnologies, new efficient delivery systems have been developed. Particularly, lipid-based nanosystems such as liposomes, ethosomes, transferosomes, solid lipid nanoparticles, nanostructured lipid carriers, cubosomes, and monoolein aqueous dispersions have been proposed for cutaneous application, reaching in some cases the market or clinical trials. This review aims to provide an overview of the different lipid-based nanosystems, focusing on their use for topical application. Particularly, biocompatible nanosystems able to dissolve lipophilic compounds and to control the release of carried drug, possibly reducing side effects, are described. Notably, the rationale to topically administer antioxidant molecules by lipid nanocarriers is described. Indeed, the structural similarity between the nanosystem lipid matrix and the skin lipids allows the achievement of a transdermal effect. Surely, more research is required to better understand the mechanism of interaction between lipid-based nanosystems and skin. However, this attempt to summarize and highlight the possibilities offered by lipid-based nanosystems could help the scientific community to take advantage of the benefits derived from this kind of nanosystem.

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Recent advances in topical carriers of anti-fungal agents

Cited by 61 publications

References 116 publications

Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders

Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders

A Review on SLN and NLC for Management of Fungal Infections

Lipid-Based Nanosystems as a Tool to Overcome Skin Barrier

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