Our findings indicated that the Comfort IOL +1.5 D provides a good intermediate spectacle independence together with a high quality of vision, with a low amount of subjective symptoms and a contrast sensitivity similar to those obtained with a monofocal IOL.
Purpose:
We report a case of neurotrophic keratopathy (NK) arising after surgery for rhabdomyosarcoma of the jaw successfully treated with Cenegermin eye drops (Oxervate; Dompé Farmaceutici, Milan, Italy) in a 3-year-old boy.
Methods:
At the age of 1 year, the boy underwent surgery for rhabdomyosarcoma of the jaw, followed by radiotherapy. Subsequent NK was initially treated with preservative-free artificial tears, topical combination of dexamethasone 0.1% and netilmicin 0.3% (Netildex; Sifi, Catania, Italy), and moxifloxacin 0.5% (Vigamox; Alcon, Fort Worth, TX), followed by 10 cycles of a topical eye biopolymer containing a poly-carboxymethyl glucose sulfate solution (Cacicol; Theà, Clermont-Ferrand, France) and 4 amniotic membrane transplantations. Keratopathy was recalcitrant to therapy and tissue transplant. Therapy was switched to Cenegermin eye drops 6 times daily for 8 weeks.
Results:
Complete healing of the corneal epithelium was achieved at 3 weeks into treatment.
Conclusions:
Cenegermin was effective in restoring corneal integrity in this pediatric patient with NK.
The environment in the suburban area of Pompeii between Porta Marina and Porta Stabia at the time of the 79 CE volcanic event was investigated by means of a series of core drillings. These revealed the presence of a ubiquitous dark brown layer (referred to as "Phase 2 interval") immediately below the 79 CE eruption deposits. Its stratigraphic interpretation relied on 14C dates, diatom analysis and micromorphology, and on comparisons and correlations with the available stratigraphic logs and excavation data. Phase 2 interval represents the sedimentary accretion that took place from ca. 900-750 cal a BCE to 79 CE. Its formation is the result of periodic flooding by the Sarno river in this distal reach of its floodplain (i.e., backswamps). The resulting picture is that of a patchy environment with weakly developed alluvial soil juxtaposed to areas with stagnating waters. No indication of artificial or natural watercourses derived from the Sarno river, of navigable lagoons, or of harbor basins was found.
Objective
To determine whether children and youths with Type 1 diabetes (T1D) have early alterations of the corneal subbasal nerve plexus detectable with in vivo confocal microscopy (IVCM) and to investigate the role of longitudinally measured major risk factors for diabetes complications associated with these alterations.
Methods
One hundred and fifty children and youths with T1D and 51 age‐matched controls were enrolled and underwent IVCM. Corneal nerve fiber length (CNFL), corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal fiber total branch density (CTBD), and corneal fiber fractal dimension (CNFrD) were measured. Risk factors for diabetes complications (blood pressure, BMI, HbA1c, lipoproteins, urinary albumin‐creatinine ratio) were recorded at IVCM and longitudinally since T1D onset. Unpaired
t
‐test was used to compare variables between the groups. Multiple regression models were calculated using IVCM parameters as dependent variables and risk factors as independent variables.
Results
All IVCM parameters, except CTBD, were significantly lower in the T1D patients. Glycometabolic control (HbA1c, visit‐to‐visit HbA1c variability, and mean HbA1c), and blood pressure were inversely correlated with IVCM parameters. Multiple regression showed that part of the variability in CNFL, CNFD, CTBD, and CNFraD was explained by HbA1c, blood pressure percentiles and age at IVCM examination, independent of diabetes duration, BMI percentile and LDL cholesterol. Comparable results were obtained using the mean value of risk factors measured longitudinally since T1D onset.
Conclusions
Early signs of corneal nerve degeneration were found in children and youths with T1D. Glycometabolic control and blood pressure were the major risk factors for these alterations.
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