Small-incision lenticule addition in ex vivo model of ectatic human corneas

Bowman-stromal inlay using an intraocular lens injector for management of keratoconus

“…There are animal and human studies available to suggest the feasibility, safety, and efficacy of intracorneal allotransplant of corneal tissue as a modality in the management of keratoconus. 4–14 The various corneal layers used for the same are BL alone, stromal lenticule obtained from patients undergoing refractive surgery, and stromal tissue from human donor cornea. 4–10…”

“…20 Pedrotti et al and Mastropasqua et al used an intrastromal pocket at least 200 μm and 180 μm away from the endothelium, respectively, and did not report any damage to endothelium. 9,11…”

“…There are animal and human studies available to suggest the feasibility, safety, and efficacy of intracorneal allotransplant of corneal tissue as a modality in the management of keratoconus. [4][5][6][7][8][9][10][11][12][13][14] The various corneal layers used for the same are BL alone, stromal lenticule obtained from patients undergoing refractive surgery, stromal tissue from human donor cornea. [4][5][6][7][8][9][10] Bowman layer (BL) transplantation has been reported to show encouraging results in stabilizing keratoconus and flattening the cone over 5 to 7 years postoperatively.…”

“…[4][5][6][7] The other modality is stromal augmentation that includes the transplant of midstromal corneal tissue. [9][10][11] The literature on this is scant, but encouraging results have been reported to stabilize keratoconus disease. We describe transplanting both the BL and anterior stroma in progressive keratoconic eyes in this communication.…”

Effect of corneal stromal lenticule customization on neurite distribution and excitatory property

“…Most, if not all, could affect the trophic support with respect to nerve regeneration after lenticule implantation [26] , [44] , [45] . Different studies have examined the post-surgical corneal changes and lenticule integration (stromal lenticule addition keratoplasty) [21] , [46] , [47] , [48] . However, the influence of residual neurites and the abortive neurite scaffold inside the implanted lenticules on the neurite regeneration and stromal responses is not known.…”