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A 30 s delay in cord clamping is feasible at both vaginal and Caesarean births, but does not lead to the predicted difference in infant haematocrit. Although physiological studies suggest that a placental transfusion of 15-20 mL/kg occurs within 30 s of delivery, these data suggest that future trials should either delay cord clamping for more than 30 s, or should alter the position of the infant in relation to the uterus in order to facilitate the transfusion. Delayed cord clamping is feasible at Caesarean section.

Antiplatelet agents, in this review largely low-dose aspirin, have small-moderate benefits when used for prevention of pre-eclampsia. Further information is required to assess which women are most likely to benefit, when treatment is best started, and at what dose.

Absent or reversed end diastolic flow (AREDF) velocities in the umbilical artery were identified in 25 high risk pregnancies. In six pregnancies the fetus was abnormal and all but one of these ended in perinatal death. Of the 19 morphologicaily normal fetuses, three died in utero and there were four neonatal or infant deaths. The mortality rate was 48% for ali pregnancies and 37% for those with morphologicaily normal fetuses. There was a highly significant increased risk for the development of necrotising enterocolitis in those morphologicaily normal fetuses with AREDF (53%) compared with controls (6%) who did have umbilical artery end diastolic flow velocities in fetal life. There were no significant differences between the matched pairs for parameters of neonatal outcome chosen to reflect neonatal morbidity. These findings demonstrate the close association between AREDF and necrotising enterocolitis that appears to be independent of other variables such as degree of growth retardation, prematurity, and perinatal asphyxia.

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Analysis 1.2. Comparison 1 HFOV vs CV (all trials), Outcome 2 Mechanical ventilation at 28-30 days in survivors. Analysis 1.3. Comparison 1 HFOV vs CV (all trials), Outcome 3 Oxygen at 28-30 days in survivors.. .. .. . Analysis 1.4. Comparison 1 HFOV vs CV (all trials), Outcome 4 CLD at 28-30 days (O2 + xray) in survivors.. . Analysis 1.5. Comparison 1 HFOV vs CV (all trials), Outcome 5 Death or CLD at 28-30 days.. .. .. . .

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