Antiplatelet agents for preventing pre-eclampsia and its complications

Duley, Lelia; Dj, Henderson-Smart; Knight, Marian; King, John L.

doi:10.1002/14651858.cd004659

Cited by 91 publications

(85 citation statements)

References 108 publications

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“…It is observed that in high risk population the risk of preeclampsia could be reduced by taking aspirin (33). According to the current UK guidelines, it should be advised to all pregnant females with chronic kidney disease (CKD) to take aspirin during their pregnancy (34), despite its efficacy to prevent preeclampsia, it is never studied in females with kidney transplants.…”

Section: Discussionmentioning

confidence: 99%

Currently Available Urine-Based Tumour Markers in the Detection of New and Recurrent Urothelial Bladder Cancer

Horstmann¹

2011

Nephro Urol Mon

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Context: The current study aimed at providing an evidence -based and up-to-date review of the literature regarding the assessment and outcomes of pregnancy in patients with renal transplant. Design: It was a review of the current literature. Conclusions: According to the current study findings, the function or survival of renal allograft was not adversely affected by getting pregnant. Therefore, ideal care for these patients needs a multidisciplinary approach including maternal-fetal medicine, nephrology, and neonatology specialists.

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Section: Discussionmentioning

confidence: 99%

Currently Available Urine-Based Tumour Markers in the Detection of New and Recurrent Urothelial Bladder Cancer

Horstmann¹

2011

Nephro Urol Mon

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“…Secondary prevention with calcium supplementation to patient at a very high risk of developing of preeclampsia and low calcium intake women shows a halving in the relative risk of preeclampsia (28) Low-dose aspirin has a significant effect in reducing the rates of a number of clinically relevant outcomes, including preeclampsia and perinatal deaths, in women with historical risk factors for preeclampsia (41,42). Reviewed studies did not show any evidence of harm from aspirin therapy (41).…”

Section: Discussionmentioning

confidence: 99%

“…Aspirin also inhibits endothelial cyclo-oxigenase (5). Six studies (20,35,(41)(42)(43)(44) demonstrated that low dose aspirin, have small-moderate benefits to reduce the risk both of preeclampsia and its complications, when used for prevention of preeclampsia (Table 2). Given the importance of these outcomes, the safety during pregnancy and low cost of aspirin, reviewers recommended that despite the number to treat to avoid one case of preeclampsia still was considered high, low dose aspirin should be offered to high risk of developing preeclampsia women.…”

Section: Aspirin and Others Antiplatelets Agentsmentioning

confidence: 99%

“…Heparin alone or in combination with an antiplatelet has been suggested for certain women at exceptionally high risk for preeclampsia, but trials had been too small for reliable conclusions (20,42,45). Two randomized studies are currently ongoing and may provide additional information (45).…”

Section: Aspirin and Others Antiplatelets Agentsmentioning

confidence: 99%

“…In two antiplatelet reviews (42,44), few studies (7/59) compared dipyridamole alone or in combination with aspirin versus placebo, thus there are insufficient evidences to assess their benefits.…”

Section: Aspirin and Others Antiplatelets Agentsmentioning

confidence: 99%

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Prediction and Prevention of Preeclampsia

Briceño-Pérez

Briceño-Sanabria

Gracia

2009

Hypertension in Pregnancy

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Preeclampsia increases maternal and perinatal morbidity and mortality rates. Much research has been done to identify unique screening tests that would predict the risk of developing preeclampsia before the classic symptoms appear. The possible use of a screening test with high predictive accuracy in patients with high-risk or low-risk of preeclampsia remains to be investigated. At present, the search for additional tests continues. There is growing interest in the use of combinations of tests. Effective primary prevention is not possible because the causes are still unknown, but to identify and to modify susceptible risk factors might decrease the frequency of preeclampsia. A community guideline improves the screening and early detection of preeclampsia, and uniforms the referral thresholds and assessment procedures. Secondary prevention with calcium supplementation and aspirin administration during pregnancy are beneficial in low calcium intake women and in the patient at a very high risk of developing severe early onset disease. Lifestyle choices, dietary nutritional measures (antioxidant as vitamin C, vitamin E, lycopene, selenium, zinc, magnesium and the mitochondrial antioxidants nicotine, coenzyme Q(10) and melatonin; and other dietary nutritional measures as low dietary salt, omega 3 fatty acids, folic acid, garlic, nutritional advice, protein and energy supplementation, isocaloric balanced protein and protein and energy restriction for obese women) and others drugs; have not shown benefits or there is insufficient evidence to recommend clinical use. Proper antenatal care and timed delivery are of utmost importance in tertiary prevention.

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Antioxidants for preventing pre-eclampsia

Rumbold

Duley

Crowther

et al. 2005

Cochrane Database of Systematic Reviews

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These results should be interpreted with caution, as most of the data come from poor quality studies. Nevertheless, antioxidant supplementation seems to reduce the risk of pre-eclampsia. There also appears to be a reduction in the risk of having a small-for-gestational-age baby associated with antioxidants, although there is an increase in the risk of preterm birth. Several large trials are ongoing, and the results of these are needed before antioxidants can be recommended for clinical practice.

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Antiplatelet agents for preventing pre-eclampsia and its complications

Abstract: Antiplatelet agents, in this review largely low-dose aspirin, have small-moderate benefits when used for prevention of pre-eclampsia. Further information is required to assess which women are most likely to benefit, when treatment is best started, and at what dose.

Cited by 91 publications

References 108 publications

Currently Available Urine-Based Tumour Markers in the Detection of New and Recurrent Urothelial Bladder Cancer

Currently Available Urine-Based Tumour Markers in the Detection of New and Recurrent Urothelial Bladder Cancer

Prediction and Prevention of Preeclampsia

Antioxidants for preventing pre-eclampsia

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