Drugs for treatment of very high blood pressure during pregnancy

A randomized cross over trial of oral nifedipine and intravenous labetalol in pregnant women with severe pre-eclampsia and eclampsia

“…15 The Cochrane review on drugs for the treatment of very high blood pressure in pregnancy concluded that until better evidence is available, the choice of antihypertensive should depend on the clinician's experience and familiarity with a particular drug, and on what is known about adverse effects. 6 On performing a search in PubMed authors found that there were two RCT s (Vermilion et al, IA Raheem et al) similar to present study. 16,17 The principal finding of IA Raheem et al was that the time taken to achieve the target blood pressure was almost the same with both drugs (45 min for labetalol and 30 min for nifedipine).…”

A randomized cross over trial of oral nifedipine and intravenous labetalol in pregnant women with severe pre-eclampsia and eclampsia

“…15 The Cochrane review on drugs for the treatment of very high blood pressure in pregnancy concluded that until better evidence is available, the choice of antihypertensive should depend on the clinician's experience and familiarity with a particular drug, and on what is known about adverse effects. 6 On performing a search in PubMed authors found that there were two RCT s (Vermilion et al, IA Raheem et al) similar to present study. 16,17 The principal finding of IA Raheem et al was that the time taken to achieve the target blood pressure was almost the same with both drugs (45 min for labetalol and 30 min for nifedipine).…”

Hydralazine for treatment of severe hypertension in pregnancy: meta-analysis

“…The most recent Cochrane review found no good evidence that one short acting antihypertensive is better than another, with the exception of ketanserin, which is associated with more persistent hypertension 53. The Cochrane inclusion and exclusion criteria differed somewhat from those in this study, but the most important difference seems to be in the reviews' methods.…”

Oral nifedipine vs. intravenous labetalol for treatment of pregnancy-induced severe pre-eclampsia

“…23,24 The Cochrane review on agents for severe hypertension therapy in pregnancy concluded that until better evidence is available, the choice of antihypertensive agent should depend on the clinician's experience and familiarity with a particular agent, and on adverse effects. 17 In the present study, our data showed that oral nifedipine and intravenous labetalol are effective in controlling severe hypertension in patients with severe pre-eclampsia. The time interval before a new hypertensive crisis coming after initial effective blood pressure control in the nifedipine group was similar to the labetalol group.…”

“…The maternal and foetal risks are decreased by lowering of blood pressure to safe levels with antihypertensive agents . The Cochrane review on agents for severe hypertension therapy in pregnancy concluded that until better evidence is available, the choice of antihypertensive agent should depend on the clinician's experience and familiarity with a particular agent, and on adverse effects . In the present study, our data showed that oral nifedipine and intravenous labetalol are effective in controlling severe hypertension in patients with severe pre‐eclampsia.…”

A randomized cross over trial of oral nifedipine and intravenous labetalol in pregnant women with severe pre-eclampsia and eclampsia

“…15 The Cochrane review on drugs for the treatment of very high blood pressure in pregnancy concluded that until better evidence is available, the choice of antihypertensive should depend on the clinician's experience and familiarity with a particular drug, and on what is known about adverse effects. 6 On performing a search in PubMed authors found that there were two RCT s (Vermilion et al, IA Raheem et al) similar to present study. 16,17 The principal finding of IA Raheem et al was that the time taken to achieve the target blood pressure was almost the same with both drugs (45 min for labetalol and 30 min for nifedipine).…”

Hydralazine for treatment of severe hypertension in pregnancy: meta-analysis

“…The most recent Cochrane review found no good evidence that one short acting antihypertensive is better than another, with the exception of ketanserin, which is associated with more persistent hypertension 53. The Cochrane inclusion and exclusion criteria differed somewhat from those in this study, but the most important difference seems to be in the reviews' methods.…”

Oral nifedipine vs. intravenous labetalol for treatment of pregnancy-induced severe pre-eclampsia

“…23,24 The Cochrane review on agents for severe hypertension therapy in pregnancy concluded that until better evidence is available, the choice of antihypertensive agent should depend on the clinician's experience and familiarity with a particular agent, and on adverse effects. 17 In the present study, our data showed that oral nifedipine and intravenous labetalol are effective in controlling severe hypertension in patients with severe pre-eclampsia. The time interval before a new hypertensive crisis coming after initial effective blood pressure control in the nifedipine group was similar to the labetalol group.…”

“…The maternal and foetal risks are decreased by lowering of blood pressure to safe levels with antihypertensive agents . The Cochrane review on agents for severe hypertension therapy in pregnancy concluded that until better evidence is available, the choice of antihypertensive agent should depend on the clinician's experience and familiarity with a particular agent, and on adverse effects . In the present study, our data showed that oral nifedipine and intravenous labetalol are effective in controlling severe hypertension in patients with severe pre‐eclampsia.…”

A randomized cross over trial of oral nifedipine and intravenous labetalol in pregnant women with severe pre-eclampsia and eclampsia

“…15 The Cochrane review on drugs for the treatment of very high blood pressure in pregnancy concluded that until better evidence is available, the choice of antihypertensive should depend on the clinician's experience and familiarity with a particular drug, and on what is known about adverse effects. 6 On performing a search in PubMed authors found that there were two RCT s (Vermilion et al, IA Raheem et al) similar to present study. 16,17 The principal finding of IA Raheem et al was that the time taken to achieve the target blood pressure was almost the same with both drugs (45 min for labetalol and 30 min for nifedipine).…”

Hydralazine for treatment of severe hypertension in pregnancy: meta-analysis

“…The most recent Cochrane review found no good evidence that one short acting antihypertensive is better than another, with the exception of ketanserin, which is associated with more persistent hypertension 53. The Cochrane inclusion and exclusion criteria differed somewhat from those in this study, but the most important difference seems to be in the reviews' methods.…”

Oral nifedipine vs. intravenous labetalol for treatment of pregnancy-induced severe pre-eclampsia

“…23,24 The Cochrane review on agents for severe hypertension therapy in pregnancy concluded that until better evidence is available, the choice of antihypertensive agent should depend on the clinician's experience and familiarity with a particular agent, and on adverse effects. 17 In the present study, our data showed that oral nifedipine and intravenous labetalol are effective in controlling severe hypertension in patients with severe pre-eclampsia. The time interval before a new hypertensive crisis coming after initial effective blood pressure control in the nifedipine group was similar to the labetalol group.…”

“…The maternal and foetal risks are decreased by lowering of blood pressure to safe levels with antihypertensive agents . The Cochrane review on agents for severe hypertension therapy in pregnancy concluded that until better evidence is available, the choice of antihypertensive agent should depend on the clinician's experience and familiarity with a particular agent, and on adverse effects . In the present study, our data showed that oral nifedipine and intravenous labetalol are effective in controlling severe hypertension in patients with severe pre‐eclampsia.…”