BACKGROUND: Sedentary lifestyle in the elderly decreases the function of cardiovascular system may lead reduction performance. Many previous studies reported that moderate intensity aerobic exercise was recommended for older persons because it may increases reactive oxygen species (ROS) at optimum level. The increasing of ROS can activate antioxidant mechanism against oxidatif stress due to exercise. AIM: The aim of this study was to investigate the change of glutathione peroxidase (GPx) activity and VO2max on moderate intensity aerobic exercise and its correlation. METHODS: The study design was quasi-experimental. Subjects were sedentary elderly women age 65 ± 5.06 years old. Total subject was 73 persons selected by consecutive sampling. Subjects did moderate intensity aerobic exercise for 12 weeks by walking for 30 min a day, 3 times a week at 50–85% of maximum heart rate. The parameters were measured on the baseline and 12 weeks after exercise. GPx activity from the plasma was examined by ELISA and the VO2max was measured by 6-min walking distance. The data were analyzed by unpaired t-test and Spearman test. RESULTS: GPx activity and VO2max were significantly increased about 41.75% and 24.11% (p < 0.05) on the experimental group, respectively. There was a correlation between GPx activity and VO2max (r = 0.223, p = 0.041). CONCLUSION: Regular moderate intensity aerobic exercise significantly increased GPx activity and VO2max. This kind of exercise is advised for the elderly because it can elevate antioxidant level as a defense against oxidative stress due to aging; therefore, it can improve aerobic capacity in the elderly.
Pembelajaran online (PJJ) bertujuan untuk meningkatkan kewaspadaan dan proses penghentian penyebaran virus melalui interaksi langsung di antara orang banyak. Dampak pembelajaran di rumah saja dapat mengakibatan gangguan kebugaran fisik dan Kesehatan mental berupa stress, pada awalnya cemas, susah belajar, tidak percaya diri, nafsu makan menurun dan kebosanan. Regulasi aktivitas fisik adalah nonfarmakologi efektif. Salah satu jenis adalah olahraga aerobik dengan intensitas moderat dan memberi efek fisiologis memperbaiki kebugaran fisik dan Kesehatan mental dengan meningkatkan neuro-kimia di otak. Tujuan kegaitan ini memberi ceramah pada mahasiswa berolahraga dapat meningkatkan kebugaran fisik maupun Kesehatan mentalnya. Metode: Kegiatan pengabdian kepada masyarakat yaitu mahasiswa di laksanakan dengan memberi ceramah cara on line menggunakan aplikasi Zoom in peserta yang hadir mahasiswa Fakultas Kedokteran dalam wadah ISMKI wilayah I Sumatera dan mahasiswamahasiswi Fakultas Kedokteran UMSU. Hasil: Kegiatan pengabdian ini menunjukkan perubahan perilaku yang lebih baik. selama masa pandemi, dilaksanakan 2 kali pertemuan dalam waktu berbeda dihadiri 260 mahasiswa. Kegiatan diharapkan memberi dampak positif bagi mahasiswa selama menjalani pembelajaran e-daring di rumah saja, dengan melakukan aktivitas fisik intensitas moderat berefek psikologis (cemas dan bosan) yang lebih baik, pada saat olahraga berpotensi pengeluaran neuron-kimia otak (endorfin, serotonin dan melantoin) .zatzat neuron-kimia memberi perasaan senang dan psikologikal well-being baik dan akhir kecemasan mahasiswa hilang serta percaya diri timbul, sehingga mudah menerima pembelajaran (PJJ) selama pandemic covid-19. Kesimpulan: regulasi aktivitas fisik terprogam, terstruktur memberikan efek peningkatan produksi neuron-kimia yang keluar dari otak, memberikan perasaan senang sesudah aktivitas fisik, mengurangai rasa sakit dan stress, dapat dikatakan psikologikal well-being yang baik. Kata kunci: Edukasi aktivitas fisik, kebugaran, Kesehatan mental, mahasiswa program PJJ
Background: Tooth extraction is a surgical procedure that involves hard tissue such as bone and soft tissue. Wounds on soft tissue are then followed by a healing process that occurs through three phases, namely the inflammatory phase, the proliferative phase, and the remodeling phase. Acemannan has the ability to stimulate hematopoiesis and antioxidant effects. Acemannan is able to reduce inflammation through prostaglandin synthesis and increase leukocyte infiltration and play a significant role in the oral wound healing process. Methods: This study is an in vivo experimental study. A total of 30 rats (5 each/group) were divided into groups that received 1%, 2%, 4%, 8%, povidone-iodine, and carbopol acemannan Aloe vera hydrogel. Furthermore, the number of macrophage cells in the tissue after tooth extraction was assessed. Data analysis was carried out with the help of SPSS with ANOVA and post hoc LSD tests. Results: There was a significant difference between the application of acemannan 1% hydrogel and 4% acemannan hydrogel, 8%, povidone-iodine, and carbopol, between the application of acemannan 2% hydrogel 4% acemannan hydrogel, 8%, povidone-iodine and carbopol, applications acemannan hydrogel 8% with carbopol, and between povidone-iodine and carbopol (p≤0.05). Conclusion: Acemannan Aloe vera hydrogel is able to accelerate wound healing after tooth extraction in vivo by suppressing macrophage cell activity.
BACKGROUND: The prevalence of hypertension increases with age, more than 1 in every two elderly have hypertension, dominated by women. The primary prevention of hypertension is a worldwide public health concern. Salat Dhuha is a moderate-intensity physical activity. Salat with a two-movement cycle (rakaat) demonstrated improved hemodynamic in adults. AIM: Our study purpose was to asses the effects of 2 and 8 rakaats of Salat Dhuha in improving systolic and diastolic blood pressure and heart rate in healthy elderly women. METHODS: Elderly women in the Senior Care Residence (aged 60–74 years) participated in a 6-week controlled study. We completed a formal physical, clinical, and blood assessments before admission. Participants with a history of hypertension were excluded from the study. The participants were randomized into 2 groups, i.e., “8 rakaats group” (n = 13) and “2 rakaats group” (n = 13) of Salat Dhuha. Two participants dropped out from the present study. At baseline and at the end of 6 weeks study period, blood pressure and heart rate were recorded. All data obtained were statistically analyzed. RESULTS: Both groups demonstrated the benefits of Salat Dhuha in improving hemodynamic parameters (systolic and diastolic blood pressure and heart rate). However, the reduction of systolic blood pressure in the “2 rakaats group” (2.16 mmHg) was less than in the “8 rakaats group” (5.50 mmHg), the reduction of diastolic blood pressure in the “2 rakaats group” (0.75 mmHg) was less than the “8 rakaats group” (2.41 mmHg) and the reduction of heart rate in “2 rakaats group” (2.08 bpm) was less than the “8 rakaats group” (6.08 bpm). All differences were statistically significant (p < 0.05). CONCLUSION: This study demonstrated that the Salat Dhuha has a significant potential in improving hemodynamic parameters for elderly women which the more frequent rakaat will give more benefit than less frequent rakaat.
Background: Prolonged activation of skeletal muscles causes a decrease in the production of fatigue. Exercise with strenuous intensity causes an increase in Reactive Oxygen Species (ROS). An increase in free radicals causes oxidative stress resulting in damage to cell function to mitochondrial dysfunction, and fatigue. This study aimed to determine the antioxidant potential of red dragon fruit (RDF) to delay fatigue due to oxidative stress, which improves cell function in mitochondria. Methods: 25 male rats (Rattus norvegicus) aged three months were divided into five groups: Group K1 was N.A. (No Activity) but drinking and eating; Group K2 performed strenuous exercise without RDF treatment; Groups 3, 4, and 5 (P1, P2 and P3, respectively) performed strenuous exercise and were treated with 75 mg kg-1.bw, 150 mg kg-1.bw, and 300 mg kg-1.bw of RDF extract, respectively. The exercise for the rats involved intense swimming for 20 minutes every day, four days a week for 31 days. Malondialdehyde (MDA) was measured with the ELISA and histopathology for muscle soleus and lung tissue. Results: Strenuous exercise followed by RDF extract ingestion was compared for fatigue in terms of duration and time; before (24.55±1.38 minute) and after (95.31±7.82 minute) and led to a significant difference of 39% (p<0.01). The study also compared MDA before and after RDF extract ingestion in the K2 vs. the P1 group (p<0.05). At the same time, P2 differed more significantly (p<0.01). This indicated a spread of free radicals and featured histopathological damage of muscle cells. However, ingestion of RDF extract leads to improvement of soleus muscle cells; thus, repairs cell function, delaying fatigue. Conclusion: This study confirmed that strenuous exercise, which causes an increase in ROS, intensifies free radicals with RDF extract ingestion and declines oxidative stress, repairing cell function and delaying fatigue.
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