Effects of Moderate Intensity Exercise on Glutathione Peroxidase Activity and VO2max in Elderly Women

Rusip, Gusbakti; Suhartini, Sri Mukti

doi:10.3889/oamjms.2020.3837

Cited by 7 publications

(6 citation statements)

References 13 publications

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“…The previous research on experimental animal models of DM showed a significant increase of the antioxidant enzyme GPx-1 after treadmill and swimming exercise compared to the sedentary DM control group [17], [18], [19]. Twelve weeks chronic exercise of moderate-intensity exercise significantly increased GPx levels (41.75%) in healthy elderly women [12]. Yoga and conventional exercise for 6 months increased SOD levels in T2DM patients significantly [20].…”

Section: Effects Of Morning and Afternoon Exercise For 10 Weeks On Pl...mentioning

confidence: 81%

“…Exercise is a lifestyle intervention that has been shown to increase the body's antioxidants and improve oxidative stress [9]. Shear stress due to increased blood flow during exercise can increase the antioxidant enzymes of superoxide dismutase (SOD) and glutathione Since 2002 peroxidase (GPx), which are responsible for ROS scavenging [10], [11], [12]. Several studies have found that exercise reduces the incidence of diabetes and serves as the foundation for T2DM management [7].…”

Section: Introductionmentioning

confidence: 99%

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Morning Exercise is More Effective in Ameliorating Oxidative Stress in Patients with Type 2 Diabetes Mellitus

Jusup

Douwes²,

Purwanto³

et al. 2022

Open Access Maced J Med Sci

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Introduction: Exercise has been believed to be an important step in treating and preventing Type 2 Diabetes Mellitus complications. The circadian rhythm influences systems in the body, including antioxidants in the human body. By synchronizing exercise with exercise time, it will maximize the benefits of exercise for health. Aim: Examining the effect of morning and afternoon exercise on increasing antioxidants and improving oxidative stress in patients with T2DM. Methods: Twenty-two T2DM patients were randomly assigned to morning and afternoon exercise groups. The exercise treatment in this study was in the form of diabetes Persadia gymnastic, for 10 weeks. All participants were taken venous blood before exercise and after the tenth week. The data examined consisted of GPx-1 (Glutathione Peroxidase-1) and MDA (malodialdehyde). The pre and post data were statistically processed using a comparative test. Results: After 10 weeks of exercise, GPx-1 levels increased significantly in both groups (p<0.05). The increase in this enzyme was considerably greater (p<0.05) in the morning group than in the afternoon group (130.37 ± 2.4 h/ml VS 72.38 ± 3.93 h/ml). MDA levels decreased significantly in morning and afternoon groups (p<0.05). The decrease in MDA was significantly greater (p<0.05) in the morning than in the afternoon exercise group (8.22 ± 0.36 nmol/ml VS 5.2 ± 0.86 nmol/ml). Conclusions: Exercise in the morning was more effective in improving oxidative stress by increasing glutathione peroxidase-1 enzyme and reducing malondialdehyde in patients with Type 2 Diabetes Mellitus. Keywords: Exercise; Glutathione Peroxidase; Malondialdehyde, T2DM.

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Section: Effects Of Morning and Afternoon Exercise For 10 Weeks On Pl...mentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Morning Exercise is More Effective in Ameliorating Oxidative Stress in Patients with Type 2 Diabetes Mellitus

Jusup

Douwes²,

Purwanto³

et al. 2022

Open Access Maced J Med Sci

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show abstract

“…Higher levels of physical activity were negatively associated with GPx3 activity. In contrast, in a 12-week walking programme, GPx3 activity increased in sedentary, postmenopausal women (65 years) ( 65 ) . Changes in GPx3 activity can be associated with oxidative stress, whereby GPx3 functions to detoxify free radicals that increase after intense physical activity ( 66 ) .…”

Section: Discussionmentioning

confidence: 99%

Selenium status and its determinants in very old adults: insights from the Newcastle 85+ Study

Perri,

Mathers,

Martin-Ruiz

et al. 2023

Br J Nutr

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There is a dearth of data on selenium status in very old adults. The aims of this study were to assess selenium status and its determinants in 85-year-olds living in the Northeast of England by measuring serum selenium and selenoprotein P (SELENOP) concentrations and glutathione peroxidase 3 (GPx3) activity. A secondary aim was to examine the interrelationships between each of the biomarkers. In total, 757 participants (463 women, 293 men) from The Newcastle 85+ Study were included. Biomarker concentrations were compared with selected cut-offs (serum selenium: suboptimal 70 µg/L and deficient 45 µg/L; SELENOP: suboptimal 4.5 mg/L and deficient 2.6 mg/L). Determinants were assessed using linear regressions and interrelationships were assessed using restricted cubic splines. Median (IQR) concentrations of serum selenium, SELENOP and of GPx3 activity were 53.6 (23.6) µg/L, 2.9 (1.9) mg/L and 142.1 (50.7) U/L, respectively. Eighty-two percent, and 83 % of participants had suboptimal serum selenium (< 70 µg/L) and SELENOP (< 4.5 mg/L), and 31 % and 40 % of participants had deficient serum selenium (< 45 µg/L) and SELENOP (< 2.6 mg/L), respectively. Protein intake was a significant determinant of selenium status. Additional determinants of serum selenium were gender, waist:hip ratio, self-rated health, and disease, whilst gender, BMI and physical activity were determinants of GPx3 activity. There was a linear association between serum selenium and SELENOP, and nonlinear associations between serum selenium and GPx3 activity and between SELENOP and GPx3 activity. These findings indicate that most participants had suboptimal selenium status to saturate circulating SELENOP.

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“…Thus, moderate-intensity regular exercise has been shown to increase antioxidant defences by increasing the activity of endogenous antioxidant enzymes, such as SOD, glutathione peroxidase, and catalase. 42,43 These enzymes can suppress or inhibit the formation of free radicals by breaking the chain reaction so that the product is more stable. This process is known as the antioxidant chain-breaking reaction.…”

Section: Discussionmentioning

confidence: 99%

The effect of ingestion of red dragon fruit extract on levels of malondialdehyde and superoxide dismutase after strenuous exercise in rats (Rattus norvegicus)

et al. 2021

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Background: Prolonged activation of skeletal muscles causes a decrease in the production of fatigue. Exercise with strenuous intensity causes an increase in Reactive Oxygen Species (ROS). An increase in free radicals causes oxidative stress resulting in damage to cell function to mitochondrial dysfunction, and fatigue. This study aimed to determine the antioxidant potential of red dragon fruit (RDF) to delay fatigue due to oxidative stress, which improves cell function in mitochondria. Methods: 25 male rats (Rattus norvegicus) aged three months were divided into five groups: Group K1 was N.A. (No Activity) but drinking and eating; Group K2 performed strenuous exercise without RDF treatment; Groups 3, 4, and 5 (P1, P2 and P3, respectively) performed strenuous exercise and were treated with 75 mg kg-1.bw, 150 mg kg-1.bw, and 300 mg kg-1.bw of RDF extract, respectively. The exercise for the rats involved intense swimming for 20 minutes every day, four days a week for 31 days. Malondialdehyde (MDA) was measured with the ELISA and histopathology for muscle soleus and lung tissue. Results: Strenuous exercise followed by RDF extract ingestion was compared for fatigue in terms of duration and time; before (24.55±1.38 minute) and after (95.31±7.82 minute) and led to a significant difference of 39% (p<0.01). The study also compared MDA before and after RDF extract ingestion in the K2 vs. the P1 group (p<0.05). At the same time, P2 differed more significantly (p<0.01). This indicated a spread of free radicals and featured histopathological damage of muscle cells. However, ingestion of RDF extract leads to improvement of soleus muscle cells; thus, repairs cell function, delaying fatigue. Conclusion: This study confirmed that strenuous exercise, which causes an increase in ROS, intensifies free radicals with RDF extract ingestion and declines oxidative stress, repairing cell function and delaying fatigue.

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Effects of Moderate Intensity Exercise on Glutathione Peroxidase Activity and VO2max in Elderly Women

Cited by 7 publications

References 13 publications

Morning Exercise is More Effective in Ameliorating Oxidative Stress in Patients with Type 2 Diabetes Mellitus

Morning Exercise is More Effective in Ameliorating Oxidative Stress in Patients with Type 2 Diabetes Mellitus

Selenium status and its determinants in very old adults: insights from the Newcastle 85+ Study

The effect of ingestion of red dragon fruit extract on levels of malondialdehyde and superoxide dismutase after strenuous exercise in rats (Rattus norvegicus)

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