A tolllike receptor 2-responsive lipid receptor pathway protects mammals against skin infections with gram-positive bacteria. Infect Immun 73:4512-21 Harrison WJ, Bull JJ, Seltmann H et al. (2007) Expression of lipogenic factors galectin-12, resistin, SREBP-1, and SCD in human sebacous glands and cultured sebocytes.

The decline of tissue regenerative potential of skin and hair is a hallmark of physiological ageing and may be associated with age-related changes in tissue-specific stem cells and/or their environment. Human hair follicles (hHF) contain keratinocytes having the property of stem cells such as clonogenic potential. Growth capacity of hHF keratinocytes shows that most of the colony-forming cells are classified as holoclones, meroclones or paraclones when analysed in a clonal assay (Cell, Volume 76, page 1063). Despite the well-known impact of ageing on human hair growth, little is known about changes in hHF keratinocyte clonogenic potential with age. This study aimed at assessing the clone-forming efficiency (CFE) of hHF keratinocytes from three age groups of human donors. It demonstrates that ageing affects hHF keratinocyte CFE.

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