Human long-term deregulated circadian rhythm alters regenerative properties of skin and hair precursor cells

Deshayes, Nathalie; Genty, Gaïanne; Berthelot, Florence; Paris, Maryline

doi:10.1684/ejd.2018.3358

Cited by 11 publications

(9 citation statements)

References 46 publications

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“…Normal keratinocyte proliferation peaks at night, and this periodicity is lost in cancerous skin cells [41]. Interfollicular epidermal keratinocytes and hair follicle keratinocytes obtained from women with circadian rhythm dysregulation due to shift work have been shown to have reduced clonogenic potential [43]. Repair of sunlight-induced DNA damage also mostly occurs at night.…”

Section: Indirect Effects Of Blue Lightmentioning

confidence: 99%

Direct and Indirect Effects of Blue Light Exposure on Skin: A Review of Published Literature

Suitthimeathegorn

Cheng

et al. 2022

Skin Pharmacol Physiol

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The growing use of electronic devices and other artificial light sources in recent decades has changed the pattern of exposure to blue light (400–500 nm). Although some progress has been made in the study of the biological effects of blue light on the skin, many questions in this field remain unexplored. The aim of this article was to review the currently available evidence on the deleterious effects of blue light on the skin, as well as the methods and strategies designed to protect from the detrimental effects of blue light. PubMed and ProQuest databases were searched in January 2022. Search results were supplemented by articles considered relevant by the authors. The results of in vitro, in vivo and clinical studies show that blue light produces direct and indirect effects on the skin. The most significant direct effects are the excessive generation of reactive oxygen and nitrogen species, and hyperpigmentation. Reactive oxygen and nitrogen species cause DNA damage and modulate the immune response. Indirect effects of blue light include disruption of the central circadian rhythm regulation via melatonin signaling and local circadian rhythm regulation via direct effects on skin cells. Antioxidants and sunscreens containing titanium dioxide, iron oxides, and zinc oxide can be used to protect against the detrimental effects of blue light as part of a strategy that combines daytime protection and night-time repair. Blue light produces a wide variety of direct and indirect effects on the skin. As exposure to blue light from artificial sources is likely to continue to increase, this area warrants further investigation.

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Section: Indirect Effects Of Blue Lightmentioning

confidence: 99%

Direct and Indirect Effects of Blue Light Exposure on Skin: A Review of Published Literature

Suitthimeathegorn

Cheng

et al. 2022

Skin Pharmacol Physiol

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“…Modification of circadian clock function disrupts the hair cycle, as Clock mutants exhibit a delay in anagen progression, and Bmal null or Per1/ Per2 double-mutant mice exhibit an increase and decrease of dormant bulge cells respectively (Janich et al, 2011;Lin et al, 2009). A recent report extends these findings to humans, showing alterations in human hair follicle keratinocytes, interfollicular epidermal keratinocytes and hair follicle dermal papilla stem cells in female shiftworkers compared to female daytime workers (Deshayes et al, 2018). These circadian effects on hair follicle regeneration are, at least partially, due to direct effects on the cell cycle as Bmal null mutants have lower levels of phosphorylated Rb protein, upregulated p21 and have lower numbers of mitotic cells (Lin et al, 2009).…”

Section: Skin Stem Cellsmentioning

confidence: 82%

Regulation of tissue regeneration by the circadian clock

Ruby

Major

Hinrichsen

2021

Eur J of Neuroscience

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Circadian rhythms are regulated by a highly conserved transcriptional/translational feedback loop that maintains approximately 24‐hr periodicity from cellular to organismal levels. Much research effort is being devoted to understanding how the outputs of the master clock affect peripheral oscillators, and in turn, numerous biological processes. Recent studies have revealed roles for circadian timing in the regulation of numerous cellular behaviours in support of complex tissue regeneration. One such role involves the interaction between the circadian clockwork and the cell cycle. The molecular mechanisms that control the cell cycle create a system of regulation that allows for high fidelity DNA synthesis, mitosis and apoptosis. In recent years, it has become clear that clock gene products are required for proper DNA synthesis and cell cycle progression, and conversely, elements of the cell cycle cascade feedback to influence molecular circadian timing mechanisms. It is through this crosstalk that the circadian system orchestrates stem cell proliferation, niche exit and control of the signalling pathways that govern differentiation and self‐renewal. In this review, we discuss the evidence for circadian control of tissue homeostasis and repair and suggest new avenues for research.

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“…The circadian system also impacts wound healing in mice ( 338 ) and hamsters ( 339 ). Experimental disruptions of this finetuned rhythmic skin regulation by circadian misalignment or sleep deprivation impairs skin integrity ( 65 , 340 ), regeneration ( 341 , 342 ), and wound healing ( 339 , 343 , 344 ), accelerates skin aging ( 345 ), enhances the activity of skin proteases ( 196 ), and leads to skin ulcers and hyperkeratosis ( 346 ). These outcomes prompt symptoms such as itching and pain.…”

Section: Potential Effects Of Shift Work On Skin and Immune Cellsmentioning

confidence: 99%

Potential effects of shift work on skin autoimmune diseases

2023

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Shift work is associated with systemic chronic inflammation, impaired host and tumor defense and dysregulated immune responses to harmless antigens such as allergens or auto-antigens. Thus, shift workers are at higher risk to develop a systemic autoimmune disease and circadian disruption with sleep impairment seem to be the key underlying mechanisms. Presumably, disturbances of the sleep-wake cycle also drive skin-specific autoimmune diseases, but epidemiological and experimental evidence so far is scarce. This review summarizes the effects of shift work, circadian misalignment, poor sleep, and the effect of potential hormonal mediators such as stress mediators or melatonin on skin barrier functions and on innate and adaptive skin immunity. Human studies as well as animal models were considered. We will also address advantages and potential pitfalls in animal models of shift work, and possible confounders that could drive skin autoimmune diseases in shift workers such as adverse lifestyle habits and psychosocial influences. Finally, we will outline feasible countermeasures that may reduce the risk of systemic and skin autoimmunity in shift workers, as well as treatment options and highlight outstanding questions that should be addressed in future studies.

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Human long-term deregulated circadian rhythm alters regenerative properties of skin and hair precursor cells

Cited by 11 publications

References 46 publications

Direct and Indirect Effects of Blue Light Exposure on Skin: A Review of Published Literature

Direct and Indirect Effects of Blue Light Exposure on Skin: A Review of Published Literature

Regulation of tissue regeneration by the circadian clock

Potential effects of shift work on skin autoimmune diseases

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