Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers

Rathman-Josserand, Michelle; Genty, Gaïanne; Lecardonnel, Jennifer; Chabane, S.; Cousson, Annabelle; Michelet, Jean‐François; Bernard, Bruno

doi:10.1038/jid.2013.113

Cited by 34 publications

(28 citation statements)

References 21 publications

(22 reference statements)

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“…This low oxygen state is hypothesized to be important for protection, or maintenance, of the stem cell reservoirs in the follicle [54], which are required for hair follicle regrowth. In hypoxic conditions, hypoxia inducible transcription factor is stabilized, enabling transcription of several target genes, including EPO, which prevent cells death.…”

Section: Drug Discovery Using Hair Follicle Organ Culturesmentioning

confidence: 99%

Regenerative Medicine and Hair Loss: How Hair Follicle Culture has Advanced our Understanding of Treatment Options for Androgenetic Alopecia

Christiano

2013

Regen. Med.

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Many of the current drug therapies for androgenetic alopecia were discovered serendipitously, with hair growth observed as an off-target effect when drugs were used to treat a different disorder. Subsequently, several studies using cultured cells have enabled identification of hair growth modulators with similar properties to the currently available drugs, which may also provide clinical benefit. In situations where the current therapeutics do not work, follicular unit transplantation is an alternative surgical option. More recently, the concept of follicular cell implantation, or hair follicle neogenesis, has been attempted, exploiting the inherent properties of cultured hair follicle cells to induce de novo hair growth in balding scalp. In this review, we discuss both the advances in cell culture techniques that have led to a wider range of potential therapeutics to promote hair growth, in addition to detailing current knowledge on follicular cell implantation, and the challenges in making this approach a reality.

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Section: Drug Discovery Using Hair Follicle Organ Culturesmentioning

confidence: 99%

Regenerative Medicine and Hair Loss: How Hair Follicle Culture has Advanced our Understanding of Treatment Options for Androgenetic Alopecia

Christiano

2013

Regen. Med.

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“…Both reservoirs are Krt19 positive and can be distinguished by the differential expression of Krt15 and CD200. Both are expressed higher in the upper reservoir, whereas CD271, CD29, and CD34 are expressed stronger in the lower reservoir (Inoue et al 2009;Rathman-Josserand et al 2013). In addition, it has been shown that LGR5-positive cells reside in the hair germ (Jaks et al 2008).…”

Section: Sc-associated Marker Expressionmentioning

confidence: 99%

The Hair Follicle

Welle

Wiener

2016

Toxicol Pathol

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The hair follicle (HF) has a wide range of functions including thermoregulation, physical and immunological protection against external insults, sensory perception, social interactions, and camouflage. One of the most characteristic features of HFs is that they self-renew during hair cycle (HC) throughout the entire life of an individual to continuously produce new hair. HC disturbances are common in humans and comparable to some alopecic disorders in dogs. A normal HC is maintained by follicular stem cells (SCs), which are predominately found in an area known as the bulge. Due to similar morphological characteristics of the human and canine bulge area, the particularity of compound HFs in humans and dogs as well as similarities in follicular biomarker expression, the dog might be a promising model to study human HC and SC disorders. In this review, we give an overview of normal follicular anatomy, the HC, and follicular SCs and discuss the possible pathogenetic mechanisms of noninflammatory alopecia.

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“…In 2002, Stenn [17] recognized the shedding phase of the hair growth cycle, then renamed ‘exogen', to be a uniquely controlled final step in the hair cycle involving a specific proteolytic step. Finally, in 2013, Bernard and colleagues [18] identified hypoxia markers in the human hair follicle stem cells and proposed hypoxia signaling mediated by the hypoxia-inducible transcription factor HIF1 to be important for reentry of the follicle into a new hair cycle in the course of a novel neomorphogenic hair cycle phase named ‘neogen'. Therefore, besides the well-recognized systemic and external factors linked to the environment (hormones, cytokines, toxins, and nutrients), the local milieu at the level of the stem cells, such as hypoxia, has been recognized to also impact hair cycling.…”

Section: Tablementioning

confidence: 99%

Telogen Effluvium: Is There a Need for a New Classification

Trüeb¹

2016

Skin Appendage Disord

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Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers

Cited by 34 publications

References 21 publications

Regenerative Medicine and Hair Loss: How Hair Follicle Culture has Advanced our Understanding of Treatment Options for Androgenetic Alopecia

Regenerative Medicine and Hair Loss: How Hair Follicle Culture has Advanced our Understanding of Treatment Options for Androgenetic Alopecia

The Hair Follicle

Telogen Effluvium: Is There a Need for a New Classification

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