Wormholes are tunnels connecting different regions in space-time. They were obtained originally as a solution for Einstein's General Relativity theory and according to this theory they need to be filled by an exotic kind of anisotropic matter. In the present sense, by "exotic matter" we mean matter that does not satisfy the energy conditions. In this article we propose the modelling of wormholes within an alternative gravity theory that proposes an extra material (rather than geometrical) term in its gravitational action. Our solutions are obtained from well-known particular cases of the wormhole metric potentials, named redshift and shape functions, and yield the wormholes to be filled by a phantom fluid, that is, a fluid with equation of state parameter ω < −1. In possession of the solutions for the wormhole material content, we also apply the energy conditions to them. The features of those are carefully discussed.

We present a new approach for the f (R, T ) gravity formalism, by thoroughly exploring the extra terms of its effective energy-momentum tensor T eff μν , which we nameT μν , so that T eff μν = T μν +T μν , with T μν being the usual energy-momentum tensor of matter. Purely from the Bianchi identities, we obtain the conservation of both parts of the effective energy-momentum tensor, rather than the non-conservation of T μν , originally occurring in the f (R, T ) theories. In this way, the intriguing scenario of matter creation, which still lacks observational evidence, is evaded. One is left, then, with two sets of cosmological equations to be solved: the Friedmann-like equations along with the conservation of T μν and along with the conservation ofT μν . We present a physical interpretation for the conservation ofT μν , which can be related to the presence of stiff matter in the universe. The cosmological consequences of this approach are presented and discussed as well as the benefits of evading the matter energy-momentum tensor non-conservation.

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This study aimed to develop a chitosan-based hydrogel containing a mixture of flavonoids isolated from the leaves of Passiflora edulis Sims and to evaluate its stability, antioxidant properties, and wound healing effects on cutaneous lesions in diabetic rats. in vitro studies were carried out to evaluate the biocompatibility and flavonoid release from the chitosan hydrogel. in vivo wound healing studies were conducted on male Wistar rats, where the injured tissue was removed for histological analysis and determination of lipid peroxidation, superoxide dismutase activity, and glutathione peroxidase activity. From the histological analysis and macroscopic evaluation of the contraction of the wounds, it was observed that the formulation presented wound healing properties. In addition, treatment of the wound with the formulation stimulated the antioxidant defense system, suggesting a beneficial effect during the treatment of skin lesions in diabetic rats, especially in the first few days after wounding. According to these results, we can conclude that the chitosan hydrogel containing the flavonoid analyzed in this study has potential use as dressings in the treatment of wounds. K E Y W O R D S antioxidant, chitosan, flavonoid, hydrogel, Passiflora edulis, wound healing

The effect of intratendineous injections of polysulphated glycosaminoglycan (PSGAG) as treatment of collagenase-induced tendonitis was studied. Two groups (GI and GII) of five Arabian horses each, males and females, two to six year-old, were submitted to experimental tendinitis of the superficial digital flexor tendon of the left thoracic limb by intratendineous injection of 1.0ml of collagenase (2.5mg/ml). Seven days after the induced-lesions were created, the horses of GI received five intralesional injections of 1.0ml (125mg) of PSGAG, every four days. Horses of GII received injections of saline in the same dose and rate. Clinical and ultrasonographic evaluations were performed periodically, during 150 days. All animals showed lameness, increased local pain, heat and swelling 24 hours after the injury was created. All signs, except to swelling, which remained visible by the end of the study, showed regression in all animals. Lesions of variable size, shape and position were evidenced by the ultrasonographic evaluation, reaching maximum severity between the seventh and the 23 rd days. By the end of the study, the echogenicity grade ranged from 1 to 2, and the grade of fiber alignment from 0 to 2. The histopathologic analysis demonstrated repair areas with intense fibroplasia and neovascularization, collagen fibers poorly organized, and thickened hypercellular endotenon. The data of this study did not show significant differences between the treated and control groups, therefore leading to the conclusion that the intralesional injection of PSGAG did not have beneficial effects in the treatment of collagenase-induced tendinitis.Keywords: polysulphated glycosaminoglycan, tendinitis, equine RESUMO Estudou-se o efeito de aplicações intratendíneas do polissulfato de glicosaminoglicanas (PSGAG) no tratamento de tendinite induzida pela colagenase. Dois grupos (GI e GII) de cinco eqüinos da raça PuroSangue Árabe, machos e fêmeas, com idades entre dois e seis anos, foram submetidos à tendinite do tendão flexor digital superficial do membro torácico esquerdo por aplicação intratendínea de 1,0ml de colagenase (2,5mg/ml). Decorridos sete dias da indução da lesão, os eqüinos do GI receberam cinco aplicações intralesionais de 1,0ml (125mg) de PSGAG, a intervalos de quatro dias, enquanto que os do GII receberam aplicações de solução fisiológica em igual volume e freqüência. Efetuaram-se avaliações

Efeitos de detomidina e xilazina intravenosa sobre as variáveis basais e respostas comportamentais em bovinos RESUMOAvaliaram-se, durante 60 minutos, 10 bovinos após administração intravenosa de 0,1mg.kg -1 de xilazina ou 10μg.kg -1 de detomidina, quanto às frequências cardíaca e respiratória, movimentos ruminais, pressão arterial média, temperatura retal e respostas comportamentais como ataxia ou decúbito, ptose palpebral, estado de alerta ou sedação e redução da altura da cabeça em relação ao solo, além da presença de salivação, micção e concentração sanguínea de glicose. Observou-se que a xilazina, via intravenosa, em bovinos, ao mesmo tempo que promove sedação mais intensa e prolongada que a detomidina, induz a uma maior quantidade de efeitos indesejáveis, como salivação e decúbito, e redução das frequências cardíaca e respiratória, da pressão arterial média, da motilidade ruminal e da temperatura, sendo estas alterações mais prolongadas. Conclui-se que a detomidina pode ser utilizada com segurança em bovinos na dose de 10μg.kg -1 , promovendo sedação e permanência do animal em posição quadrupedal.

with approximately 300 kg and 15 months old, were used. The animals were housed in individual pens for a period of 126 days, with the first 21 days of adaptation. The animals were weighed and ultra-sound images were taken at the beginning of the experiment and at every 35 days. A randomized complete design was used in a factorial scheme (2 genetic groups × 2 concentrate levels). There were no significant interactions for any of the evaluated variables. The Canchim animals presented better feed efficiency (0.17 × 0.14) and higher loin eye area gain (19.7 × 13.2 cm 2 ). The 60%

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