Objective To update the likelihood ratio for trisomy 21 in fetuses with absent nasal bone at the 11-14-week scan. Methods

Objective To examine the association between absence of the nasal bone at the 11-14-week ultrasound scan and chromosomal defects. NT < 2.5 mm, for NT ≥ 4.5 mm. In the chromosomally abnormal group the nasal bone was absent in 161/242 (66.9%) with trisomy 21, in 48/84 (57.1%) with trisomy 18, in 7/22 (31.8%) Methods

Objective To determine the value of measuring maxillary length at 11-14 weeks of gestation in screening for trisomy 21. Methods

At 11-14 weeks of gestation, the nasal bone length of chromosomally abnormal fetuses is not significantly different from normal.

No abstract

Objective To evaluate the benefit of three-dimensional (3D)

First trimester maternal serum SHBG concentrations are no different from controls in women who subsequently develop preeclampsia, pregnancy-induced hypertension, fetal growth restriction, or preterm delivery. Levels are reduced in those who subsequently miscarry or in those presenting with diabetes.

Objective To determine the value of measuring fetal ear length at 11-14 weeks of gestation in screening for chromosomal defects. Methods