Ear length in trisomy 21 fetuses at 11–14 weeks of gestation

Sacchini, C; El-Sheikhah, Ahmad; Cicero, S.; Rembouskos, G.; Nicolaides, Kypros H.

doi:10.1002/uog.903

Cited by 28 publications

(16 citation statements)

References 8 publications

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“…Shorter fetal ear length has been associated with aneuploidy and trisomy 21. 19,20 Commissural length was the only craniofacial parameter in the current study to vary significantly according to sex, with the distance being greater in male than in female newborns (2.74 vs 2.59 cm respectively). This finding is not supported by a study of North Indian newborns, which reported lengths of 2.49 cm and 2.45 cm for males and females respectively.…”

Section: Discussionmentioning

confidence: 57%

Craniofacial anthropometry in newborns of Sikkimese origin

2014

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Section: Discussionmentioning

confidence: 57%

Craniofacial anthropometry in newborns of Sikkimese origin

2014

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“…In particular, this modality has been helpful in evaluation of facial abnormalities, hand abnormalities, club feet, skeletal dysplasia, and spinal malformations [12–15]. To the best of our knowledge, there are only a few reports on the diagnosis of external ear abnormalities by ultrasonography which mainly focus on auricular deformities indicative of chromosomal abnormalities [4, 16–18]. The aim of our study was to investigate the best time of examination and section chosen of routine prenatal ultrasound screening for fetal auricular abnormalities and evaluate the feasibility of examining the fetal ears with ultrasonography.…”

Section: Introductionmentioning

confidence: 99%

Prenatal Ultrasound Screening for External Ear Abnormality in the Fetuses

Wei

Ran

Yang

et al. 2014

BioMed Research International

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Objectives. To investigate the best time of examination and section chosen of routine prenatal ultrasound screening for external ear abnormalities and evaluate the feasibility of examining the fetal external ear with ultrasonography. Methods. From July 2010 until August 2011, 42118 pregnant women with single fetus during 16–40 weeks of pregnancy were enrolled in the study. Fetal auricles and external auditory canal in the second trimester of pregnancy were evaluated by routine color Doppler ultrasound screening and systematic screening. Ultrasound images of fetal external ears were obtained on transverse-incline view at cervical vertebra level and mandible level and on parasagittal view and coronal view at external ear level. Results. Five fetuses had anomalous ears including bilateral malformed auricles with malformed external auditory canal, unilateral deformed external ear, and unilateral microtia. The detection rate of both auricles was negatively correlated with gestational age. Of the 5843 fetuses undergoing a routine ultrasound screening, 5797 (99.21%) had bilateral auricles. Of the 4955 fetuses following systematic screening, all fetuses (100%) had bilateral auricles. The best time for fetal auricles observation with ultrasonography is 20–24 weeks of pregnancy. Conclusions. Detection of external ear abnormalities may assist in the diagnosis of chromosomal abnormalities.

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“…Newborns and adults with Down syndrome have short ears [37] , and prenatal studies showed a statistically significant difference between the ear sizes of normal fetuses and fetuses with trisomy 21 but only with a small degree of deviation from normal [38][39][40] . Probably due to this tiny difference, small ears were the only craniofacial feature not significantly different between Down syndrome and control fetuses in our study.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic Variability in Fetuses with Down Syndrome: A Case-Control Pathological Evaluation

Ramalho¹,

Brandão

Matias³

et al. 2011

Fetal Diagn Ther

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Objectives: Evaluation of morphological and morphometric characteristics of fetuses with Down syndrome based on a detailed postmortem examination and comparison of these fetuses with a control group of fetuses with normal karyotype to improve the prenatal knowledge of Down syndrome characteristics. Material and Methods: A case-control study was undertaken in a tertiary referral hospital. The Down syndrome fetuses (50) were compared with chromosomally normal fetuses (47) matched for gestational age. Biometric and morphological parameters were compared. Results: The biometry of fetuses with Down syndrome differs from control fetuses only in the occipitofrontal diameter and in the nasal bone length. There were craniofacial anomalies in 96% of fetuses with Down syndrome and in 51% of fetuses with normal karyotype. With the exception of small ears, all craniofacial features analyzed were significantly different between Down syndrome fetuses and control fetuses. All extremity features of fetuses with Down syndrome were significantly different from fetuses without Down syndrome. There were 31 fetuses with Down syndrome (62%) with 55 internal anomalies. Nineteen fetuses (38.8%) showed 27 cardiac anomalies. Six fetuses had more than one anomaly. There were 18 fetuses (36%) with 28 noncardiac anomalies. Discussion: The importance of studying the morphological characteristics of fetuses with Down syndrome is the contribution to a better knowledge of fetal characteristics and probably to optimize prenatal diagnosis.

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Ear length in trisomy 21 fetuses at 11–14 weeks of gestation

Abstract: Objective To determine the value of measuring fetal ear length at 11-14 weeks of gestation in screening for chromosomal defects. Methods

Cited by 28 publications

References 8 publications

Craniofacial anthropometry in newborns of Sikkimese origin

Craniofacial anthropometry in newborns of Sikkimese origin

Prenatal Ultrasound Screening for External Ear Abnormality in the Fetuses

Phenotypic Variability in Fetuses with Down Syndrome: A Case-Control Pathological Evaluation

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