First Trimester Sex Hormone-Binding Globulin and Subsequent Development of Preeclampsia or Other Adverse Pregnancy Outcomes

Spencer, Kevin; Yu, Christina; Rembouskos, G.; Bindra, Ranjna; Nicolaides, Kypros H.

doi:10.1080/10641950500281068

Cited by 33 publications

(22 citation statements)

References 30 publications

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“…Spencer et al [26] reported lower SHBG concentration in the first trimester of pregnancy in women who developed GDM. A recent study [13] showed that preconception SHBG levels were better predictors of GDM in PCOS women compared with waist circumference or HOMA-IR.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Gestational Diabetes Mellitus in Chinese Women with Polycystic Ovary Syndrome: A Cross-Sectional Study

Zhang

Jin²,

Qin

et al. 2015

Gynecol Obstet Invest

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Aims: This study aims to explore the independent predictors of gestational diabetes mellitus (GDM) in Chinese women with polycystic ovary syndrome (PCOS). Methods: This cross-sectional study analyzed primigravid women with PCOS and classified them as those with and without GDM. Independent risk factors and model performance were analyzed using multivariate logistic regression and the area under the curve (AUC) of receiver operating characteristic (ROC), respectively. Results: Maternal body mass index, waist circumference, waist-to-hip ratio (WHR), fasting glucose, insulin, sex hormone-binding globulin (SHBG), homeostasis model assessment-insulin resistance (HOMA-IR) before pregnancy, gestation weight gain before 24 weeks and the incidence of family history of diabetes were different in the 2 groups. Logistic regression analysis showed that pre-pregnancy WHR, SHBG, HOMA-IR and gestation weight gain before 24 weeks were the independent predictors of GDM. ROC curve analysis confirmed that gestation weight gain before 24 weeks (AUC 0.767, 95% CI 0.688-0.841), pre-pregnant WHR (AUC 0.725, 95% CI 0.649-0.802), HOMA-IR (AUC 0.711, 95% CI 0.632-0.790) and SHBG levels (AUC 0.709, 95% CI 0.625-0.793) were the strong risk factors. Conclusions: In Chinese women with PCOS, factors of gestation weight gain before 24 weeks, pre-pregnant WHR, HOMA-IR and SHBG levels are strongly associated with subsequent development of GDM.

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Section: Discussionmentioning

confidence: 99%

Predictors of Gestational Diabetes Mellitus in Chinese Women with Polycystic Ovary Syndrome: A Cross-Sectional Study

Zhang

Jin²,

Qin

et al. 2015

Gynecol Obstet Invest

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“…), would be closely related to the onset of stillbirths during the first trimester and of pathologies affecting the mother-child binomial. The etiopathogenesis of such conditions would involve endothelial dysfunction and/or predisposing metabolic conditions having an abnormal placentation, as that seen in PE, as a common denominator [17,18,19,20,21,22]. PE shares a series of pathophysiological findings with IR, among which are the following: endothelial dysfunction, atherosclerosis and inflammation.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Pregestational Insulin Resistance as a Risk Factor of Preeclampsia

Valdés

Sepúlveda‐Martínez

Manukián

et al. 2014

Gynecol Obstet Invest

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Aim: To assess the impact that pregestational insulin resistance (PIR) has as a risk factor for preeclampsia (PE). Methods: Nested case-control study that included patients with PIR and a control group that was randomly selected from pregnancies admitted to the Fetal Medicine Unit between January 2005 and May 2011. Clinical and hemodynamic variables were analyzed by a multiple logistic regression analysis. Results: Of the 13,124 patients admitted during the study period, 119 had a diagnosis of PIR (0.9%). Patients with PIR were older and had a higher body mass index (BMI). PIR was also related to a significantly higher frequency of chronic hypertension (CrHT; 10.1 vs. 2.2%, p < 0.05) and hypothyroidism (5.0 vs. 1.6%, p < 0.05) than in the control group. Moreover, women with PIR were more likely to develop PE (8.4 vs. 4.2%, p < 0.05) and gestational diabetes mellitus (9.2 vs. 2.9%) than the control group. Multivariate analysis showed that maternal age, CrHT and altered uterine artery Doppler sonography during the first and second trimesters were good predictors of PE and that PIR was not. Conclusion: Although PIR correlates with PE, conditions related to the latter (CrHT, higher maternal age and increased BMI) may be predominant as risk factors for PE.

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“…Our result of lower SHBG in hypertensive women with gestational diabetes mellitus compared with those with normal blood pressure could indicate increased risk for type 2 diabetes in the former. Earlier studies on SHBG in gestational diabetes as well as in hypertensive pregnancy complications compared with normal pregnancy have shown controversial results [35][36][37][38][39][40][41].…”

Section: Discussionmentioning

confidence: 97%

Decreased variation of inflammatory markers in gestational diabetes

Pöyhönen‐Alho

Ebeling

Saarinen

et al. 2011

Diabetes Metabolism Res

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First Trimester Sex Hormone-Binding Globulin and Subsequent Development of Preeclampsia or Other Adverse Pregnancy Outcomes

Cited by 33 publications

References 30 publications

Predictors of Gestational Diabetes Mellitus in Chinese Women with Polycystic Ovary Syndrome: A Cross-Sectional Study

Predictors of Gestational Diabetes Mellitus in Chinese Women with Polycystic Ovary Syndrome: A Cross-Sectional Study

Assessment of Pregestational Insulin Resistance as a Risk Factor of Preeclampsia

Decreased variation of inflammatory markers in gestational diabetes

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