Decreased variation of inflammatory markers in gestational diabetes

Abstract

Gestational diabetes is associated with loss of natural variation of C-reactive protein and serum amyloid A, suggesting altered modulation of inflammation. Hypertension in gestational diabetes seems not to be associated with higher levels of inflammatory markers other than α-1 acid glycoprotein.

Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

“…After screening titles and abstracts, 31 references were selected for full-text reading [16][17][18][19][20][21][22][23][24][25][26][27][28][29][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] and 23 citations reporting on 22 studies were included in this review (Fig. 2).…”

Increased intestinal permeability, measured by serum zonulin, is associated with metabolic risk markers in overweight pregnant women

“…Hs-CRP and GlycA are both related to metabolic disorders; the maternal first trimester CRP has been shown to be associated with the development of gestational diabetes in some studies [35][36][37] but not all [38][39][40][41], and GlycA has been related to chronic inflammation [42], type 2 diabetes, and CVD in non-pregnant subjects [43][44][45]. Previously, only levels of individual glycoproteins have been investigated in women with normal pregnancy and with gestational diabetes (e.g., [38,[46][47][48][49][50]). The novel finding of association of GlycA complex with metabolic risk markers in our study suggests that elevated levels may predict the risk for metabolic disorders, such as insulin resistance in pregnancy as well.…”

Childhood maltreatment and inflammation among pregnant women with gestational diabetes mellitus: A pilot study

“…27 Pregnant women with GDM also display a loss of natural variations of C-reactive protein, suggesting altered modulation of inflammation. 28 Maternal GDM may also be associated with elevated levels of IL-6 [29][30][31] and TNF-a. 32,33 Given evidence that women with GDM display elevated inflammation compared to pregnant women without GDM, findings from this study indicate that women with maltreatment histories and GDM show even greater production of pro-inflammatory cytokines.…”