Chronic
wounds have become a major health problem worldwide. Curcumin
(Cur), with strong anti-inflammatory and anti-infective properties,
is introduced as a unique molecule for wound dressing applications.
In the present study, Cur-loaded chitosan/poly(ethylene oxide)/collagen
(Cho/PEO/Col) nanofibers were developed for wound dressing applications
by the blend–electrospinning process. Structural, mechanical,
and biological properties of nanofibers were evaluated using SEM,
FTIR, tensile testing, in vitro release study, Alamar blue cytotoxicity
assay, and in vivo study in a rat model. According to the results,
Cur was successfully released up to 3 days without any significant
cytotoxicity of the above hybrid to human dermal fibroblasts. In vivo
studies on full-thickness wounds in the rat model indicated significant
improvement in the mean wound area closure by applying Cur-loaded
Cho/PEO/Col nanofibers. The electrospun Cho/PEO/Col nanofibers loaded
with Cur could be considered as a promising type of wound dressing
in the wound-healing process.
Breast cancer resistance protein (BCRP, ABCP or MXR)/ATP-binding cassette subfamily G member 2 (ABCG2) was characterized as a multidrug resistance efflux transporter in 1998. ABCG2 physiologically acts as a part of a selfdefence mechanism for the organism; it enhances eliminating of toxic xenobiotic substances and harmful agents in the intestine, as well as through the blood-brain barrier and placenta. ABCG2 recognizes and transports numerous anticancer drugs including conventional chemotherapeutic and new targeted small therapeutic molecules in clinical usage. Development of ABCG2 inhibitors for clinical usage may allow increased penetration of therapeutic agents into sanctuary sites and increases their intestinal absorption. Here we review the mechanisms that modulate MDR mediated by the ABC transporter ABCG2 in normal and cancer cells by different levels including, epigenetic modifications, transcriptional, post-transcriptional, translation and post-translational regulation. Some clinical applications of ABCG2 inhibitors are also explained.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.