Evaluation of wound healing efficiency of vancomycin-loaded electrospun chitosan/poly ethylene oxide nanofibers in full thickness wound model of rat

Kalalinia, Fatemeh; Taherzadeh, Zhila; Jirofti, Nafiseh; Amiri, Nafise; Foroghinia, Neda; Beheshti, Mona; Bazzaz, Bibi Sedigheh Fazly; Hashemi, Maryam; Shahroodi, Azadeh; Pishavar, Elham; Tabassi, Seyed Abolghasem Sajadi; Movaffagh, Jebrail

doi:10.1016/j.ijbiomac.2021.01.209

Cited by 72 publications

(35 citation statements)

References 52 publications

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“…In recent years, various wound dressings have been developed and evaluated with similar cytotoxicity results to ours. Kalalinia et al (2021) developed vancomycin (VCM)-loaded hybrid chitosan/poly ethylene oxide (Chi/PEO) nanofibers by blend-electrospinning [ 65 ]. There are no harmful effects of any group, according to the findings of the Alamar Blue cytotoxicity tests performed on HDFs.…”

Section: Resultsmentioning

confidence: 99%

Fabrication and Characterization of Electrospun Folic Acid/Hybrid Fibers: In Vitro Controlled Release Study and Cytocompatibility Assays

et al. 2021

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The fabrication of skin-care products with therapeutic properties has been significant for human health trends. In this study, we developed efficient hydrophilic composite nanofibers (NFs) loaded with the folic acid (FA) by electrospinning and electrospraying processes for tissue engineering or wound healing cosmetic applications. The morphological, chemical and thermal characteristics, in vitro release properties, and cytocompatibility of the resulting composite fibers with the same amount of folic acid were analyzed. The SEM micrographs indicate that the obtained nanofibers were in the nanometer range, with an average fiber diameter of 75–270 nm and a good porosity ratio (34–55%). The TGA curves show that FA inhibits the degradation of the polymer and acts as an antioxidant at high temperatures. More physical interaction between FA and matrices has been shown to occur in the electrospray process than in the electrospinning process. A UV-Vis in vitro study of FA-loaded electrospun fibers for 8 h in artificial acidic (pH 5.44) and alkaline (pH 8.04) sweat solutions exhibited a rapid release of FA-loaded electrospun fibers, showing the effect of polymer matrix–FA interactions and fabrication processes on their release from the nanofibers. PVA-CHi/FA webs have the highest release value, with 95.2% in alkaline media. In acidic media, the highest release (92%) occurred on the PVA-Gel–CHi/sFA sample, and this followed first-order and Korsmeyer–Peppas kinetic models. Further, the L929 cytocompatibility assay results pointed out that all NFs (with/without FA) generated had no cell toxicity; on the contrary, the FA in the fibers facilitates cell growth. Therefore, the nanofibers are a potential candidate material in skin-care and tissue engineering applications.

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Section: Resultsmentioning

confidence: 99%

Fabrication and Characterization of Electrospun Folic Acid/Hybrid Fibers: In Vitro Controlled Release Study and Cytocompatibility Assays

et al. 2021

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“…As a result of their high porosity and permeability, as well as their small pore size, reliable filtration of the smallest and finest particles can be achieved [44,45]. Other applications of nanofiber mats as filters include optical and chemical sensors [46], energy storage [47], aerospace [48], nanocatalysis [49], protective clothing [50], transportation [51], water and air filters for biotechnological and industrial applications [52][53][54][55][56][57][58], filtering of dye particles from wastewater from the finishing industry [59] or filtering of smoke filtration and flavor retention [60]. Great research interest in recent years shows the use of biomass for the production of nanofibers from the biomass and natural biopolymers used as a precursor for carbon and carbon nanofibers to make the contribution to the ecological point of view and the extraction of raw materials from natural resources.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Carbon Nanofibers from Biomass and Biomass Blends—Current Trends

et al. 2021

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In recent years, ecological issues have led to the search for new green materials from biomass as precursors for producing carbon materials (CNFs). Such green materials are more attractive than traditional petroleum-based materials, which are environmentally harmful and non-biodegradable. Biomass could be ideal precursors for nanofibers since they stem from renewable sources and are low-cost. Recently, many authors have focused intensively on nanofibers’ production from biomass using microwave-assisted pyrolysis, hydrothermal treatment, ultrasonication method, but only a few on electrospinning methods. Moreover, still few studies deal with the production of electrospun carbon nanofibers from biomass. This review focuses on the new developments and trends of electrospun carbon nanofibers from biomass and aims to fill this research gap. The review is focusing on recollecting the most recent investigations about the preparation of carbon nanofiber from biomass and biopolymers as precursors using electrospinning as the manufacturing method, and the most important applications, such as energy storage that include fuel cells, electrochemical batteries and supercapacitors, as well as wastewater treatment, CO2 capture, and medicine.

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“…The release kinetics of PVNF-n nanofibers was carried out according to a previous report ( Kalalinia et al, 2021 ). Briefly, the PVNF-n samples were incubated in 1 ml phosphate-buffered saline (PBS) in a shaking water bath with a shake speed of 50 rpm at 37°C.…”

Section: Methodsmentioning

confidence: 99%

Vancomycin-Loaded Polycaprolactone Electrospinning Nanofibers Modulate the Airway Interfaces to Restrain Tracheal Stenosis

Tian

Zhou

Feng

et al. 2021

Front. Bioeng. Biotechnol.

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Site-specific release of therapeutics at the infected trachea remains a great challenge in clinic. This work aimed to develop a series of vancomycin (VA)-loaded polycaprolactone (PCL) composite nanofiber films (PVNF-n, n = 0, 1, and 5, respectively) via the electrospinning technique. The physiochemical and biological properties of PVNF-n were evaluated by a series of tests, such as FT-IR, XRD, SEM-EDS, and antibacterial assay. The PVNF-n samples displayed a typical network structure of fibers with random directions. VA was successfully introduced into the PCL nanofibers and could be sustained and released. More importantly, PVNF-5 showed relatively good antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae (SPn). Thus, PVNF-5 was covered onto the self-expandable metallic stent and then implanted into a New Zealand rabbit model to repair tracheal stenosis. Compared to a metallic stent, a commercial pellosil matrix–covered stent, and a PVNF-0–covered metallic stent, the PVNF-5–covered airway stent showed reduced granulation tissue thickness, collagen density, α-SMA, CD68, TNF-α, IL-1, and IL-6 expression. In conclusion, this work provides an anti-infection film–covered airway stent that in site restrains tracheal stenosis.

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Evaluation of wound healing efficiency of vancomycin-loaded electrospun chitosan/poly ethylene oxide nanofibers in full thickness wound model of rat

Cited by 72 publications

References 52 publications

Fabrication and Characterization of Electrospun Folic Acid/Hybrid Fibers: In Vitro Controlled Release Study and Cytocompatibility Assays

Fabrication and Characterization of Electrospun Folic Acid/Hybrid Fibers: In Vitro Controlled Release Study and Cytocompatibility Assays

Electrospun Carbon Nanofibers from Biomass and Biomass Blends—Current Trends

Vancomycin-Loaded Polycaprolactone Electrospinning Nanofibers Modulate the Airway Interfaces to Restrain Tracheal Stenosis

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